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Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component.
Thibault B, Ramos-Delgado F, Pons-Tostivint E, Therville N, Cintas C, Arcucci S, Cassant-Sourdy S, Reyes-Castellanos G, Tosolini M, Villard AV, Cayron C, Baer R, Bertrand-Michel J, Pagan D, Ferreira Da Mota D, Yan H, Falcomatà C, Muscari F, Bournet B, Delord JP, Aksoy E, Carrier A, Cordelier P, Saur D, Basset C, Guillermet-Guibert J. Thibault B, et al. Among authors: guillermet guibert j. EMBO Mol Med. 2021 Jul 7;13(7):e13502. doi: 10.15252/emmm.202013502. Epub 2021 May 25. EMBO Mol Med. 2021. PMID: 34033220 Free PMC article.
PI3K functions as a hub in mechanotransduction.
Di-Luoffo M, Ben-Meriem Z, Lefebvre P, Delarue M, Guillermet-Guibert J. Di-Luoffo M, et al. Among authors: guillermet guibert j. Trends Biochem Sci. 2021 Nov;46(11):878-888. doi: 10.1016/j.tibs.2021.05.005. Epub 2021 Jun 7. Trends Biochem Sci. 2021. PMID: 34112586 Review.
A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding.
Ben Meriem Z, Mateo T, Faccini J, Denais C, Dusfour-Castan R, Guynet C, Merle T, Suzanne M, Di-Luoffo M, Guillermet-Guibert J, Alric B, Landiech S, Malaquin L, Mesnilgrente F, Laborde A, Mazenq L, Courson R, Delarue M. Ben Meriem Z, et al. Among authors: guillermet guibert j. Lab Chip. 2023 Oct 10;23(20):4445-4455. doi: 10.1039/d3lc00313b. Lab Chip. 2023. PMID: 37740366
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.
Müller D, Shin S, Goullet de Rugy T, Samain R, Baer R, Strehaiano M, Masvidal-Sanz L, Guillermet-Guibert J, Jean C, Tsukumo Y, Sonenberg N, Marion F, Guilbaud N, Hoffmann JS, Larsson O, Bousquet C, Pyronnet S, Martineau Y. Müller D, et al. JCI Insight. 2019 Nov 1;4(21):e121951. doi: 10.1172/jci.insight.121951. JCI Insight. 2019. PMID: 31672935 Free PMC article.
46 results