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Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB. Halby L, et al. Among authors: guillemot jc. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170072. doi: 10.1098/rstb.2017.0072. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29685976 Free PMC article.
Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
Coutard B, Barral K, Lichière J, Selisko B, Martin B, Aouadi W, Lombardia MO, Debart F, Vasseur JJ, Guillemot JC, Canard B, Decroly E. Coutard B, et al. Among authors: guillemot jc. J Virol. 2017 Feb 14;91(5):e02202-16. doi: 10.1128/JVI.02202-16. Print 2017 Mar 1. J Virol. 2017. PMID: 28031359 Free PMC article.
Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.
Lugari A, Betzi S, Decroly E, Bonnaud E, Hermant A, Guillemot JC, Debarnot C, Borg JP, Bouvet M, Canard B, Morelli X, Lécine P. Lugari A, et al. Among authors: guillemot jc. J Biol Chem. 2010 Oct 22;285(43):33230-33241. doi: 10.1074/jbc.M110.120014. Epub 2010 Aug 10. J Biol Chem. 2010. PMID: 20699222 Free PMC article.
Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.
Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Bouvet M, et al. Among authors: guillemot jc. J Biol Chem. 2014 Sep 12;289(37):25783-96. doi: 10.1074/jbc.M114.577353. Epub 2014 Jul 29. J Biol Chem. 2014. PMID: 25074927 Free PMC article.
Drugs against SARS-CoV-2: What do we know about their mode of action?
Valle C, Martin B, Touret F, Shannon A, Canard B, Guillemot JC, Coutard B, Decroly E. Valle C, et al. Among authors: guillemot jc. Rev Med Virol. 2020 Nov;30(6):1-10. doi: 10.1002/rmv.2143. Epub 2020 Aug 11. Rev Med Virol. 2020. PMID: 32779326 Free PMC article. Review.
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay.
Ferreira-Ramos AS, Li C, Eydoux C, Contreras JM, Morice C, Quérat G, Gigante A, Pérez Pérez MJ, Jung ML, Canard B, Guillemot JC, Decroly E, Coutard B. Ferreira-Ramos AS, et al. Among authors: guillemot jc. Antiviral Res. 2019 Mar;163:59-69. doi: 10.1016/j.antiviral.2019.01.003. Epub 2019 Jan 11. Antiviral Res. 2019. PMID: 30639438
A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro.
De Castro S, Stevaert A, Maldonado M, Delpal A, Vandeput J, Van Loy B, Eydoux C, Guillemot JC, Decroly E, Gago F, Canard B, Camarasa MJ, Velázquez S, Naesens L. De Castro S, et al. Among authors: guillemot jc. Pharmaceuticals (Basel). 2022 Aug 18;15(8):1021. doi: 10.3390/ph15081021. Pharmaceuticals (Basel). 2022. PMID: 36015168 Free PMC article.
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Delpal A, Decroly E, Alvarez K, Eydoux C, Guillemot JC, Moussa A, Good SS, La Colla P, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B. Shannon A, et al. Among authors: guillemot jc. Nat Commun. 2022 Feb 2;13(1):621. doi: 10.1038/s41467-022-28113-1. Nat Commun. 2022. PMID: 35110538 Free PMC article.
111 results