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Page 1
Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD.
Johanns M, Haas JT, Raverdy V, Vandel J, Chevalier-Dubois J, Guille L, Derudas B, Legendre B, Caiazzo R, Verkindt H, Gnemmi V, Leteurtre E, Derhourhi M, Bonnefond A, Froguel P, Eeckhoute J, Lassailly G, Mathurin P, Pattou F, Staels B, Lefebvre P. Johanns M, et al. Among authors: guille l. JHEP Rep. 2023 Oct 27;6(1):100948. doi: 10.1016/j.jhepr.2023.100948. eCollection 2024 Jan. JHEP Rep. 2023. PMID: 38125300 Free PMC article.
The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα.
Clavreul L, Bernard L, Cotte AK, Hennuyer N, Bourouh C, Devos C, Helleboid A, Haas JT, Verrijken A, Gheeraert C, Derudas B, Guille L, Chevalier J, Eeckhoute J, Vallez E, Dorchies E, Van Gaal L, Lassailly G, Francque S, Staels B, Paumelle R. Clavreul L, et al. Among authors: guille l. Metabolism. 2024 Feb;151:155720. doi: 10.1016/j.metabol.2023.155720. Epub 2023 Nov 3. Metabolism. 2024. PMID: 37926201
An extended transcription factor regulatory network controls hepatocyte identity.
Dubois-Chevalier J, Gheeraert C, Berthier A, Boulet C, Dubois V, Guille L, Fourcot M, Marot G, Gauthier K, Dubuquoy L, Staels B, Lefebvre P, Eeckhoute J. Dubois-Chevalier J, et al. Among authors: guille l. EMBO Rep. 2023 Sep 6;24(9):e57020. doi: 10.15252/embr.202357020. Epub 2023 Jul 10. EMBO Rep. 2023. PMID: 37424431 Free PMC article.
A time- and space-resolved nuclear receptor atlas in mouse liver.
Zummo FP, Berthier A, Gheeraert C, Vinod M, Bobowski-Gérard M, Molendi-Coste O, Pineau L, Jung M, Guille L, Dubois-Chevalier J, Dombrowicz D, Staels B, Eeckhoute J, Lefebvre P. Zummo FP, et al. Among authors: guille l. J Mol Endocrinol. 2023 May 18;71(1):e230017. doi: 10.1530/JME-23-0017. Print 2023 Jul 1. J Mol Endocrinol. 2023. PMID: 36988391
Evaluation of genome and base editing tools in maize protoplasts.
Fierlej Y, Jacquier NMA, Guille L, Just J, Montes E, Richard C, Loue-Manifel J, Depège-Fargeix N, Gaillard A, Widiez T, Rogowsky PM. Fierlej Y, et al. Among authors: guille l. Front Plant Sci. 2022 Nov 28;13:1010030. doi: 10.3389/fpls.2022.1010030. eCollection 2022. Front Plant Sci. 2022. PMID: 36518521 Free PMC article.
Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis.
Bobowski-Gerard M, Boulet C, Zummo FP, Dubois-Chevalier J, Gheeraert C, Bou Saleh M, Strub JM, Farce A, Ploton M, Guille L, Vandel J, Bongiovanni A, Very N, Woitrain E, Deprince A, Lalloyer F, Bauge E, Ferri L, Ntandja-Wandji LC, Cotte AK, Grangette C, Vallez E, Cianférani S, Raverdy V, Caiazzo R, Gnemmi V, Leteurtre E, Pourcet B, Paumelle R, Ravnskjaer K, Lassailly G, Haas JT, Mathurin P, Pattou F, Dubuquoy L, Staels B, Lefebvre P, Eeckhoute J. Bobowski-Gerard M, et al. Among authors: guille l. Nat Commun. 2022 Sep 10;13(1):5324. doi: 10.1038/s41467-022-33063-9. Nat Commun. 2022. PMID: 36088459 Free PMC article.