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p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis.
Solé L, Lobo-Jarne T, Álvarez-Villanueva D, Alonso-Marañón J, Guillén Y, Guix M, Sangrador I, Rozalén C, Vert A, Barbachano A, Lop J, Salido M, Bellosillo B, García-Romero R, Garrido M, González J, Martínez-Iniesta M, López-Arribillaga E, Salazar R, Montagut C, Torres F, Iglesias M, Celià-Terrassa T, Muñoz A, Villanueva A, Bigas A, Espinosa L. Solé L, et al. Among authors: guillen y. Nat Commun. 2022 May 23;13(1):2866. doi: 10.1038/s41467-022-30382-9. Nat Commun. 2022. PMID: 35606354 Free PMC article.
Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.
Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A. Porcheri C, et al. Among authors: guillen y. EMBO J. 2020 Apr 15;39(8):e104270. doi: 10.15252/embj.2019104270. Epub 2020 Mar 9. EMBO J. 2020. PMID: 32149421 Free PMC article.
IκBα deficiency imposes a fetal phenotype to intestinal stem cells.
Marruecos L, Bertran J, Guillén Y, González J, Batlle R, López-Arribillaga E, Garrido M, Ruiz-Herguido C, Lisiero D, González-Farré M, Arce-Gallego S, Iglesias M, Nebreda AR, Miyamoto S, Bigas A, Espinosa L. Marruecos L, et al. Among authors: guillen y. EMBO Rep. 2020 Jun 4;21(6):e49708. doi: 10.15252/embr.201949708. Epub 2020 Apr 9. EMBO Rep. 2020. PMID: 32270911 Free PMC article.
Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development.
Brena D, Bertran J, Porta-de-la-Riva M, Guillén Y, Cornes E, Kukhtar D, Campos-Vicens L, Fernández L, Pecharroman I, García-López A, Islam ABMMK, Marruecos L, Bigas A, Cerón J, Espinosa L. Brena D, et al. Among authors: guillen y. Sci Rep. 2020 Sep 30;10(1):16153. doi: 10.1038/s41598-020-73146-5. Sci Rep. 2020. PMID: 32999373 Free PMC article.
Dynamic chromatin association of IκBα is regulated by acetylation and cleavage of histone H4.
Marruecos L, Bertran J, Álvarez-Villanueva D, Mulero MC, Guillén Y, Palma LG, Floor M, Vert A, Arce-Gallego S, Pecharroman I, Batlle L, Villà-Freixa J, Ghosh G, Bigas A, Espinosa L. Marruecos L, et al. Among authors: guillen y. EMBO Rep. 2021 Aug 4;22(8):e52649. doi: 10.15252/embr.202152649. Epub 2021 Jul 5. EMBO Rep. 2021. PMID: 34224210 Free PMC article.
Sézary syndrome patient-derived models allow drug selection for personalized therapy.
Gallardo F, Andrades E, Iglesias A, González J, Solé L, Guillén Y, Blanco G, Colomo L, Gimeno E, Conde D, Rodriguez E, Bielsa-Marso I, Iglesias M, Bellosillo B, Pujol RM, Regueiro JR, Bigas A, Espinosa L. Gallardo F, et al. Among authors: guillen y. Blood Adv. 2022 Jun 14;6(11):3410-3421. doi: 10.1182/bloodadvances.2021006860. Blood Adv. 2022. PMID: 35413113 Free PMC article.
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia.
García-Hernández V, Arambilet D, Guillén Y, Lobo-Jarne T, Maqueda M, Gekas C, González J, Iglesias A, Vega-García N, Sentís I, Trincado JL, Márquez-López I, Heyn H, Camós M, Espinosa L, Bigas A. García-Hernández V, et al. Among authors: guillen y. EMBO Mol Med. 2023 Feb 8;15(2):e16554. doi: 10.15252/emmm.202216554. Epub 2023 Jan 4. EMBO Mol Med. 2023. PMID: 36597789 Free PMC article.
45 results