Guilford P - Search Results

1

Cohesin mutations are synthetic lethal with stimulation of WNT signaling.

Chin CV, Antony J, Ketharnathan S, Labudina A, Gimenez G, Parsons KM, He J, George AJ, Pallotta MM, Musio A, Braithwaite A, Guilford P, Hannan RD, Horsfield JA. Chin CV, et al. Among authors: guilford p. Elife. 2020 Dec 7;9:e61405. doi: 10.7554/eLife.61405. Elife. 2020. PMID: 33284104 Free PMC article.

2

Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells.

Telford BJ, Chen A, Beetham H, Frick J, Brew TP, Gould CM, Single A, Godwin T, Simpson KJ, Guilford P. Telford BJ, et al. Among authors: guilford p. Mol Cancer Ther. 2015 May;14(5):1213-23. doi: 10.1158/1535-7163.MCT-14-1092. Epub 2015 Mar 16. Mol Cancer Ther. 2015. PMID: 25777964

3

A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells.

Beetham H, Chen A, Telford BJ, Single A, Jarman KE, Lackovic K, Luxenburger A, Guilford P. Beetham H, et al. Among authors: guilford p. Sci Rep. 2019 Aug 29;9(1):12511. doi: 10.1038/s41598-019-48929-0. Sci Rep. 2019. PMID: 31467357 Free PMC article.

4

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.

Godwin TD, Kelly ST, Brew TP, Bougen-Zhukov NM, Single AB, Chen A, Stylianou CE, Harris LD, Currie SK, Telford BJ, Beetham HG, Evans GB, Black MA, Guilford PJ. Godwin TD, et al. Among authors: guilford pj. Gastric Cancer. 2019 Mar;22(2):273-286. doi: 10.1007/s10120-018-0859-1. Epub 2018 Jul 31. Gastric Cancer. 2019. PMID: 30066183 Free PMC article.

5

A Comparison of Real-Time and Endpoint Cell Viability Assays for Improved Synthetic Lethal Drug Validation.

Single A, Beetham H, Telford BJ, Guilford P, Chen A. Single A, et al. Among authors: guilford p. J Biomol Screen. 2015 Dec;20(10):1286-93. doi: 10.1177/1087057115605765. Epub 2015 Sep 17. J Biomol Screen. 2015. PMID: 26384394

6

Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer.

Luxenburger A, Bougen-Zhukov N, Fraser MG, Beetham H, Harris LD, Schmidt D, Cameron SA, Guilford PJ, Evans GB. Luxenburger A, et al. Among authors: guilford pj. J Med Chem. 2021 Dec 23;64(24):18114-18142. doi: 10.1021/acs.jmedchem.1c01609. Epub 2021 Dec 8. J Med Chem. 2021. PMID: 34878770

7

Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking.

Brew T, Bougen-Zhukov N, Mitchell W, Decourtye L, Schulpen E, Nouri Y, Godwin T, Guilford P. Brew T, et al. Among authors: guilford p. Cancers (Basel). 2021 Dec 26;14(1):102. doi: 10.3390/cancers14010102. Cancers (Basel). 2021. PMID: 35008266 Free PMC article.

8

Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells.

Bougen-Zhukov N, Nouri Y, Godwin T, Taylor M, Hakkaart C, Single A, Brew T, Permina E, Chen A, Black MA, Guilford P. Bougen-Zhukov N, et al. Among authors: guilford p. Cancers (Basel). 2019 Sep 13;11(9):1359. doi: 10.3390/cancers11091359. Cancers (Basel). 2019. PMID: 31540244 Free PMC article.

9

Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation.

Willson JS, Godwin TD, Wiggins GA, Guilford PJ, McCall JL. Willson JS, et al. Among authors: guilford pj. J Hepatol. 2013 Oct;59(4):904-7. doi: 10.1016/j.jhep.2013.05.024. Epub 2013 May 23. J Hepatol. 2013. PMID: 23707370 Free article.

10

E-Cadherin-Deficient Cells Are Sensitive to the Multikinase Inhibitor Dasatinib.

Bougen-Zhukov N, Decourtye-Espiard L, Mitchell W, Redpath K, Perkinson J, Godwin T, Black MA, Guilford P. Bougen-Zhukov N, et al. Among authors: guilford p. Cancers (Basel). 2022 Mar 22;14(7):1609. doi: 10.3390/cancers14071609. Cancers (Basel). 2022. PMID: 35406381 Free PMC article.

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