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Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse.
Muroňová J, Kherraf ZE, Giordani E, Lambert E, Eckert S, Cazin C, Amiri-Yekta A, Court M, Chevalier G, Martinez G, Neirijnck Y, Kühne F, Wehrli L, Klena N, Hamel V, De Macedo L, Escoffier J, Guichard P, Coutton C, Mustapha SFB, Kharouf M, Bouin AP, Zouari R, Thierry-Mieg N, Nef S, Geimer S, Loeuillet C, Ray PF, Arnoult C. Muroňová J, et al. Among authors: guichard p. Elife. 2024 Mar 5;12:RP86845. doi: 10.7554/eLife.86845. Elife. 2024. PMID: 38441556 Free PMC article.
A helical inner scaffold provides a structural basis for centriole cohesion.
Le Guennec M, Klena N, Gambarotto D, Laporte MH, Tassin AM, van den Hoek H, Erdmann PS, Schaffer M, Kovacik L, Borgers S, Goldie KN, Stahlberg H, Bornens M, Azimzadeh J, Engel BD, Hamel V, Guichard P. Le Guennec M, et al. Among authors: guichard p. Sci Adv. 2020 Feb 14;6(7):eaaz4137. doi: 10.1126/sciadv.aaz4137. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32110738 Free PMC article.
Architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography.
Klena N, Le Guennec M, Tassin AM, van den Hoek H, Erdmann PS, Schaffer M, Geimer S, Aeschlimann G, Kovacik L, Sadian Y, Goldie KN, Stahlberg H, Engel BD, Hamel V, Guichard P. Klena N, et al. Among authors: guichard p. EMBO J. 2020 Nov 16;39(22):e106246. doi: 10.15252/embj.2020106246. Epub 2020 Sep 20. EMBO J. 2020. PMID: 32954513 Free PMC article.
Overview of the centriole architecture.
LeGuennec M, Klena N, Aeschlimann G, Hamel V, Guichard P. LeGuennec M, et al. Among authors: guichard p. Curr Opin Struct Biol. 2021 Feb;66:58-65. doi: 10.1016/j.sbi.2020.09.015. Epub 2020 Nov 8. Curr Opin Struct Biol. 2021. PMID: 33176264 Free article. Review.
83 results