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Page 1
A first-generation pediatric cancer dependency map.
Dharia NV, Kugener G, Guenther LM, Malone CF, Durbin AD, Hong AL, Howard TP, Bandopadhayay P, Wechsler CS, Fung I, Warren AC, Dempster JM, Krill-Burger JM, Paolella BR, Moh P, Jha N, Tang A, Montgomery P, Boehm JS, Hahn WC, Roberts CWM, McFarland JM, Tsherniak A, Golub TR, Vazquez F, Stegmaier K. Dharia NV, et al. Among authors: guenther lm. Nat Genet. 2021 Apr;53(4):529-538. doi: 10.1038/s41588-021-00819-w. Epub 2021 Mar 22. Nat Genet. 2021. PMID: 33753930 Free PMC article.
A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma.
Guenther LM, Dharia NV, Ross L, Conway A, Robichaud AL, Catlett JL 2nd, Wechsler CS, Frank ES, Goodale A, Church AJ, Tseng YY, Guha R, McKnight CG, Janeway KA, Boehm JS, Mora J, Davis MI, Alexe G, Piccioni F, Stegmaier K. Guenther LM, et al. Clin Cancer Res. 2019 Feb 15;25(4):1343-1357. doi: 10.1158/1078-0432.CCR-18-0372. Epub 2018 Nov 5. Clin Cancer Res. 2019. PMID: 30397176 Free PMC article.
Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma.
Tokarsky EJ, Crow JC, Guenther LM, Sherman J, Taslim C, Alexe G, Pishas KI, Rask G, Justis BS, Kasumova A, Stegmaier K, Lessnick SL, Theisen ER. Tokarsky EJ, et al. Among authors: guenther lm. Mol Cancer Res. 2022 Jul 6;20(7):1035-1046. doi: 10.1158/1541-7786.MCR-22-0027. Mol Cancer Res. 2022. PMID: 35298000 Free PMC article.
Phase 2 trial of palbociclib and ganitumab in patients with relapsed Ewing sarcoma.
Shulman DS, Merriam P, Choy E, Guenther LM, Cavanaugh KL, Kao PC, Posner A, Bhushan K, Fairchild G, Barker E, Klega K, Stegmaier K, Crompton BD, London WB, DuBois SG. Shulman DS, et al. Among authors: guenther lm. Cancer Med. 2023 Jul;12(14):15207-15216. doi: 10.1002/cam4.6208. Epub 2023 Jun 12. Cancer Med. 2023. PMID: 37306107 Free PMC article. Clinical Trial.
The 2022 generation.
Barry-Hundeyin M, Carrot-Zhang J, Dayton T, Ghazanfar S, Guenther LM, Nguyen DTT, Pitarresi JR, Rajput S, Santana-Codina N, Shree T, Zeng Z, Zhang Y. Barry-Hundeyin M, et al. Among authors: guenther lm. Nat Cancer. 2022 Dec;3(12):1426-1431. doi: 10.1038/s43018-022-00481-z. Nat Cancer. 2022. PMID: 36539504 No abstract available.
Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin.
Wan X, Kim SY, Guenther LM, Mendoza A, Briggs J, Yeung C, Currier D, Zhang H, Mackall C, Li WJ, Tuan RS, Deyrup AT, Khanna C, Helman L. Wan X, et al. Among authors: guenther lm. Oncogene. 2009 Sep 24;28(38):3401-11. doi: 10.1038/onc.2009.206. Epub 2009 Jul 13. Oncogene. 2009. PMID: 19597468 Free PMC article.