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RNA splicing promotes translation and RNA surveillance.
Gudikote JP, Imam JS, Garcia RF, Wilkinson MF. Gudikote JP, et al. Nat Struct Mol Biol. 2005 Sep;12(9):801-9. doi: 10.1038/nsmb980. Epub 2005 Aug 21. Nat Struct Mol Biol. 2005. PMID: 16116435
An alternative branch of the nonsense-mediated decay pathway.
Chan WK, Huang L, Gudikote JP, Chang YF, Imam JS, MacLean JA 2nd, Wilkinson MF. Chan WK, et al. Among authors: gudikote jp. EMBO J. 2007 Apr 4;26(7):1820-30. doi: 10.1038/sj.emboj.7601628. Epub 2007 Mar 15. EMBO J. 2007. PMID: 17363904 Free PMC article.
Nonsense codons trigger an RNA partitioning shift.
Bhalla AD, Gudikote JP, Wang J, Chan WK, Chang YF, Olivas OR, Wilkinson MF. Bhalla AD, et al. Among authors: gudikote jp. J Biol Chem. 2009 Feb 13;284(7):4062-72. doi: 10.1074/jbc.M805193200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091751 Free PMC article.
Boundary-independent polar nonsense-mediated decay.
Wang J, Gudikote JP, Olivas OR, Wilkinson MF. Wang J, et al. Among authors: gudikote jp. EMBO Rep. 2002 Mar;3(3):274-9. doi: 10.1093/embo-reports/kvf036. Epub 2002 Feb 15. EMBO Rep. 2002. PMID: 11850396 Free PMC article.
Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers.
Gudikote JP, Cascone T, Poteete A, Sitthideatphaiboon P, Wu Q, Morikawa N, Zhang F, Peng S, Tong P, Li L, Shen L, Nilsson M, Jones P, Sulman EP, Wang J, Bourdon JC, Johnson FM, Heymach JV. Gudikote JP, et al. J Biol Chem. 2021 Nov;297(5):101163. doi: 10.1016/j.jbc.2021.101163. Epub 2021 Sep 3. J Biol Chem. 2021. PMID: 34481841 Free PMC article.
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Byers LA, Diao L, Wang J, Saintigny P, Girard L, Peyton M, Shen L, Fan Y, Giri U, Tumula PK, Nilsson MB, Gudikote J, Tran H, Cardnell RJ, Bearss DJ, Warner SL, Foulks JM, Kanner SB, Gandhi V, Krett N, Rosen ST, Kim ES, Herbst RS, Blumenschein GR, Lee JJ, Lippman SM, Ang KK, Mills GB, Hong WK, Weinstein JN, Wistuba II, Coombes KR, Minna JD, Heymach JV. Byers LA, et al. Clin Cancer Res. 2013 Jan 1;19(1):279-90. doi: 10.1158/1078-0432.CCR-12-1558. Epub 2012 Oct 22. Clin Cancer Res. 2013. PMID: 23091115 Free PMC article.
Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.
Skoulidis F, Byers LA, Diao L, Papadimitrakopoulou VA, Tong P, Izzo J, Behrens C, Kadara H, Parra ER, Canales JR, Zhang J, Giri U, Gudikote J, Cortez MA, Yang C, Fan Y, Peyton M, Girard L, Coombes KR, Toniatti C, Heffernan TP, Choi M, Frampton GM, Miller V, Weinstein JN, Herbst RS, Wong KK, Zhang J, Sharma P, Mills GB, Hong WK, Minna JD, Allison JP, Futreal A, Wang J, Wistuba II, Heymach JV. Skoulidis F, et al. Among authors: gudikote j. Cancer Discov. 2015 Aug;5(8):860-77. doi: 10.1158/2159-8290.CD-14-1236. Epub 2015 Jun 11. Cancer Discov. 2015. PMID: 26069186 Free PMC article.
KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib.
Nilsson MB, Giri U, Gudikote J, Tang X, Lu W, Tran H, Fan Y, Koo A, Diao L, Tong P, Wang J, Herbst R, Johnson BE, Ryan A, Webster A, Rowe P, Wistuba II, Heymach JV. Nilsson MB, et al. Clin Cancer Res. 2016 Apr 15;22(8):1940-50. doi: 10.1158/1078-0432.CCR-15-1994. Epub 2015 Nov 17. Clin Cancer Res. 2016. PMID: 26578684 Free PMC article.
15 results