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In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus.
Vugmeyster Y, Guay H, Szklut P, Qian MD, Jin M, Widom A, Spaulding V, Bennett F, Lowe L, Andreyeva T, Lowe D, Lane S, Thom G, Valge-Archer V, Gill D, Young D, Bloom L. Vugmeyster Y, et al. Among authors: guay h. MAbs. 2010 May-Jun;2(3):335-46. doi: 10.4161/mabs.2.3.11850. Epub 2010 May 23. MAbs. 2010. PMID: 20424514 Free PMC article.
Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys.
Vugmeyster Y, Allen S, Szklut P, Bree A, Ryan M, Ma M, Spaulding V, Young D, Guay H, Bloom L, Leach MW, O'Toole M, Adkins K. Vugmeyster Y, et al. Among authors: guay h. J Transl Med. 2010 Apr 26;8:41. doi: 10.1186/1479-5876-8-41. J Transl Med. 2010. PMID: 20420683 Free PMC article.
IL-21 receptor is critical for the development of memory B cell responses.
Rankin AL, MacLeod H, Keegan S, Andreyeva T, Lowe L, Bloom L, Collins M, Nickerson-Nutter C, Young D, Guay H. Rankin AL, et al. Among authors: guay h. J Immunol. 2011 Jan 15;186(2):667-74. doi: 10.4049/jimmunol.0903207. Epub 2010 Dec 17. J Immunol. 2011. PMID: 21169545
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.
Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. Rankin AL, et al. Among authors: guay h. J Immunol. 2012 Feb 15;188(4):1656-67. doi: 10.4049/jimmunol.1003871. Epub 2012 Jan 9. J Immunol. 2012. PMID: 22231702 Free PMC article.
51 results