Guan TL - Search Results

1

Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase.

Lee HF, Lacbay CM, Boutin R, Matralis AN, Park J, Waller DD, Guan TL, Sebag M, Tsantrizos YS. Lee HF, et al. Among authors: guan tl. J Med Chem. 2022 Feb 10;65(3):2471-2496. doi: 10.1021/acs.jmedchem.1c01913. Epub 2022 Jan 25. J Med Chem. 2022. PMID: 35077178

2

Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer.

Boutin R, Lee HF, Guan TL, Nguyen TT, Huang XF, Waller DD, Lu J, Christine Chio II, Michel RP, Sebag M, Tsantrizos YS. Boutin R, et al. Among authors: guan tl. J Med Chem. 2023 Dec 14;66(23):15776-15800. doi: 10.1021/acs.jmedchem.3c01271. Epub 2023 Nov 20. J Med Chem. 2023. PMID: 37982711 Free PMC article.

3

Discovery of 1,5-diaryl-1,2,4-triazole derivatives as myoferlin inhibitors and their antitumor effects in pancreatic cancer.

Gu H, Zhang T, Li Y, He Y, Guan T, Kan W, He P, Yi Z, Chen Y. Gu H, et al. Future Med Chem. 2022 Oct;14(20):1425-1440. doi: 10.4155/fmc-2022-0168. Epub 2022 Sep 27. Future Med Chem. 2022. PMID: 36165130

4

B-cell Lymphoma 6 Inhibitors: Current Advances and Prospects of Drug Development for Diffuse Large B-cell Lymphomas.

Gu H, He J, Li Y, Mi D, Guan T, Guo W, Liu B, Chen Y. Gu H, et al. J Med Chem. 2022 Dec 8;65(23):15559-15583. doi: 10.1021/acs.jmedchem.2c01433. Epub 2022 Nov 28. J Med Chem. 2022. PMID: 36441945 Review.

5

Discovery of a Potent and Oral Available Complex I OXPHOS Inhibitor That Abrogates Tumor Growth and Circumvents MEKi Resistance.

He P, Feng J, Xia X, Sun Y, He J, Guan T, Peng Y, Zhang X, Liu M, Pang X, Chen Y. He P, et al. J Med Chem. 2023 May 11;66(9):6047-6069. doi: 10.1021/acs.jmedchem.2c01844. Epub 2023 May 2. J Med Chem. 2023. PMID: 37130350

6

Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer.

Gu H, Zhang T, Guan T, Wu M, Li S, Li Y, Guo M, Zhang L, Peng Y, Mi D, Liu M, Yi Z, Chen Y. Gu H, et al. J Med Chem. 2023 Dec 28;66(24):16917-16938. doi: 10.1021/acs.jmedchem.3c01639. Epub 2023 Dec 6. J Med Chem. 2023. PMID: 38054798

7

Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer.

He J, Wang L, Mi D, Guan T, Liu W, He P, Gu H, Li Y, Peng Y, Jia AQ, Chen C, Chen Y. He J, et al. J Med Chem. 2023 Jun 8;66(11):7421-7437. doi: 10.1021/acs.jmedchem.3c00090. Epub 2023 May 22. J Med Chem. 2023. PMID: 37212861

8

Discovery of an efficacious KDM5B PROTAC degrader GT-653 up-regulating IFN response genes in prostate cancer.

Guan T, Zhang Y, Li S, Zhang W, Song Y, Li Y, He Y, Chen Y. Guan T, et al. Eur J Med Chem. 2024 May 10;272:116494. doi: 10.1016/j.ejmech.2024.116494. Online ahead of print. Eur J Med Chem. 2024. PMID: 38749268

9

Utility of 30-day mortality as a quality metric for palliative radiation treatment: A population-based analysis from Queensland, Australia.

Guan TL, Kutzko JH, Lunn DP, Dunn NA, Burmeister BH, Dadwal P, Tran N, Holt TR. Guan TL, et al. J Med Imaging Radiat Oncol. 2024 Apr;68(3):316-324. doi: 10.1111/1754-9485.13633. Epub 2024 Mar 19. J Med Imaging Radiat Oncol. 2024. PMID: 38500454

10

The SMS domain of Trs23p is responsible for the in vitro appearance of the TRAPP I complex in Saccharomyces cerevisiae.

Brunet S, Noueihed B, Shahrzad N, Saint-Dic D, Hasaj B, Guan TL, Moores A, Barlowe C, Sacher M. Brunet S, et al. Among authors: guan tl. Cell Logist. 2012 Jan 1;2(1):28-42. doi: 10.4161/cl.19414. Cell Logist. 2012. PMID: 22645708 Free PMC article.

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