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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.
Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W. Chen G, et al. Among authors: guan l. Nature. 2018 Aug;560(7718):382-386. doi: 10.1038/s41586-018-0392-8. Epub 2018 Aug 8. Nature. 2018. PMID: 30089911 Free PMC article.
HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors.
Guan L, Wu B, Li T, Beer LA, Sharma G, Li M, Lee CN, Liu S, Yang C, Huang L, Frederick DT, Boland GM, Shao G, Svitkina TM, Cai KQ, Chen F, Dong MQ, Mills GB, Schuchter LM, Karakousis GC, Mitchell TC, Flaherty KT, Speicher DW, Chen YH, Herlyn M, Amaravadi RK, Xu X, Guo W. Guan L, et al. Nat Commun. 2022 Jul 14;13(1):4078. doi: 10.1038/s41467-022-31713-6. Nat Commun. 2022. PMID: 35835783 Free PMC article.
Stiff matrix induces exosome secretion to promote tumour growth.
Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, Gimotty PA, Wells RG, Weaver VM, Radhakrishnan R, Wang XW, Guo W. Wu B, et al. Among authors: guan l. Nat Cell Biol. 2023 Mar;25(3):415-424. doi: 10.1038/s41556-023-01092-1. Epub 2023 Feb 16. Nat Cell Biol. 2023. PMID: 36797475 Free PMC article.
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth.
Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, Gimotty PA, Wells RG, Weaver VM, Radhakrishnan R, Wang XW, Guo W. Wu B, et al. Among authors: guan l. Nat Cell Biol. 2024 Mar;26(3):490-491. doi: 10.1038/s41556-024-01375-1. Nat Cell Biol. 2024. PMID: 38347184 No abstract available.
Precision medicine for hepatocellular carcinoma: driver mutations and targeted therapy.
Ding XX, Zhu QG, Zhang SM, Guan L, Li T, Zhang L, Wang SY, Ren WL, Chen XM, Zhao J, Lin S, Liu ZZ, Bai YX, He B, Zhang HQ. Ding XX, et al. Among authors: guan l. Oncotarget. 2017 Jun 6;8(33):55715-55730. doi: 10.18632/oncotarget.18382. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903454 Free PMC article. Review.
3,044 results