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Metformin acts in the gut and induces gut-liver crosstalk.
Tobar N, Rocha GZ, Santos A, Guadagnini D, Assalin HB, Camargo JA, Gonçalves AESS, Pallis FR, Oliveira AG, Rocco SA, Neto RM, de Sousa IL, Alborghetti MR, Sforça ML, Rodrigues PB, Ludwig RG, Vanzela EC, Brunetto SQ, Boer PA, Gontijo JAR, Geloneze B, Carvalho CRO, Prada PO, Folli F, Curi R, Mori MA, Vinolo MAR, Ramos CD, Franchini KG, Tormena CF, Saad MJA. Tobar N, et al. Among authors: guadagnini d. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2211933120. doi: 10.1073/pnas.2211933120. Epub 2023 Jan 19. Proc Natl Acad Sci U S A. 2023. PMID: 36656866 Free PMC article.
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
Ropelle ER, Flores MB, Cintra DE, Rocha GZ, Pauli JR, Morari J, de Souza CT, Moraes JC, Prada PO, Guadagnini D, Marin RM, Oliveira AG, Augusto TM, Carvalho HF, Velloso LA, Saad MJ, Carvalheira JB. Ropelle ER, et al. Among authors: guadagnini d. PLoS Biol. 2010 Aug 24;8(8):e1000465. doi: 10.1371/journal.pbio.1000465. PLoS Biol. 2010. PMID: 20808781 Free PMC article. Retracted.
Comment on: Ramos-Zavala et al. Effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes: a randomized clinical trial. Diabetes Care 2011;34:1591-1594.
Tobar N, Oliveira AG, Guadagnini D, Bagarolli RA, Rocha GZ, Araujo TG, Prada PO, Saad MJ. Tobar N, et al. Among authors: guadagnini d. Diabetes Care. 2012 Feb;35(2):e13; author reply e14. doi: 10.2337/dc11-1856. Diabetes Care. 2012. PMID: 22275450 Free PMC article. No abstract available.
Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice.
Carvalho-Filho MA, Carvalho BM, Oliveira AG, Guadagnini D, Ueno M, Dias MM, Tsukumo DM, Hirabara SM, Reis LF, Curi R, Carvalheira JB, Saad MJ. Carvalho-Filho MA, et al. Among authors: guadagnini d. Endocrinology. 2012 Nov;153(11):5261-74. doi: 10.1210/en.2012-1400. Epub 2012 Sep 4. Endocrinology. 2012. PMID: 22948222
Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice.
Ropelle ER, Pauli JR, Cintra DE, da Silva AS, De Souza CT, Guadagnini D, Carvalho BM, Caricilli AM, Katashima CK, Carvalho-Filho MA, Hirabara S, Curi R, Velloso LA, Saad MJ, Carvalheira JB. Ropelle ER, et al. Among authors: guadagnini d. Diabetes. 2013 Feb;62(2):466-70. doi: 10.2337/db12-0339. Epub 2012 Sep 18. Diabetes. 2013. PMID: 22991447 Free PMC article.
56 results