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Design, synthesis, and biological evaluation of anti-EV71 agents.
Li P, Yang B, Hao F, Wang P, He H, Huang L, Zhang X, Zhang S, Peng X, Yin K, Hu J, Chen X, Gu Z, Wang L, Shen L, Hu G, Li N, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Zhang L, Cai Q, Lin T. Li P, et al. Among authors: gu z. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3346-3350. doi: 10.1016/j.bmcl.2016.05.036. Epub 2016 May 14. Bioorg Med Chem Lett. 2016. PMID: 27234148
Discovery and Assessment of Atropisomers of (±)-Lesinurad.
Wang J, Zeng W, Li S, Shen L, Gu Z, Zhang Y, Li J, Chen S, Jia X. Wang J, et al. Among authors: gu z. ACS Med Chem Lett. 2017 Feb 14;8(3):299-303. doi: 10.1021/acsmedchemlett.6b00465. eCollection 2017 Mar 9. ACS Med Chem Lett. 2017. PMID: 28337320 Free PMC article.
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD.
Li P, Yu J, Hao F, He H, Shi X, Hu J, Wang L, Du C, Zhang X, Sun Y, Lin F, Gu Z, Xu D, Chen X, Shen L, Hu G, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Tian X, Lin T. Li P, et al. Among authors: gu z. ACS Med Chem Lett. 2017 Jul 10;8(8):841-846. doi: 10.1021/acsmedchemlett.7b00188. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835799 Free PMC article.
Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment.
Li X, Zhou K, He H, Zhou Q, Sun Y, Hou L, Shen L, Wang X, Zhou Y, Gong Z, He S, Jin H, Gu Z, Zhao S, Zhang L, Sun C, Zheng S, Cheng Z, Zhu Y, Zhang M, Li J, Chen S. Li X, et al. Among authors: gu z. ACS Med Chem Lett. 2017 Aug 24;8(9):969-974. doi: 10.1021/acsmedchemlett.7b00288. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947946 Free PMC article.
Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease.
Mou J, Wu S, Luo Z, Guo F, He H, Wang J, Lin F, Guo F, Sun J, Shen L, Zeng M, Wang C, Xu D, Gu Z, Tian X, Zhang A, Xu H, Yang L, Zhang X, Li J, Chen S. Mou J, et al. Among authors: gu z. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1874-1878. doi: 10.1016/j.bmcl.2018.04.002. Epub 2018 Apr 4. Bioorg Med Chem Lett. 2018. PMID: 29650287
Correction to "The Discovery of 3,3'-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection".
Shi W, Jiang Z, He H, Xiao F, Lin F, Sun Y, Hou L, Shen L, Han L, Zeng M, Lai K, Gu Z, Chen X, Zhao T, Guo L, Yang C, Li J, Chen S. Shi W, et al. Among authors: gu z. ACS Med Chem Lett. 2018 Mar 30;9(4):397. doi: 10.1021/acsmedchemlett.8b00139. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29671838 Free PMC article.
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent.
Li P, Wu S, Xiao T, Li Y, Su Z, Wei W, Hao F, Hu G, Lin F, Chen X, Gu Z, Lin T, He H, Li J, Chen S. Li P, et al. Among authors: gu z. Bioorg Med Chem. 2020 Jun 15;28(12):115551. doi: 10.1016/j.bmc.2020.115551. Epub 2020 May 8. Bioorg Med Chem. 2020. PMID: 32503695
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability.
Bai B, Belovodskiy A, Hena M, Kandadai AS, Joyce MA, Saffran HA, Shields JA, Khan MB, Arutyunova E, Lu J, Bajwa SK, Hockman D, Fischer C, Lamer T, Vuong W, van Belkum MJ, Gu Z, Lin F, Du Y, Xu J, Rahim M, Young HS, Vederas JC, Tyrrell DL, Lemieux MJ, Nieman JA. Bai B, et al. Among authors: gu z. J Med Chem. 2022 Feb 24;65(4):2905-2925. doi: 10.1021/acs.jmedchem.1c00616. Epub 2021 Jul 9. J Med Chem. 2022. PMID: 34242027
6,604 results