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Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.
Gruszczyk J, Grandvuillemin L, Lai-Kee-Him J, Paloni M, Savva CG, Germain P, Grimaldi M, Boulahtouf A, Kwong HS, Bous J, Ancelin A, Bechara C, Barducci A, Balaguer P, Bourguet W. Gruszczyk J, et al. Nat Commun. 2022 Nov 16;13(1):7010. doi: 10.1038/s41467-022-34773-w. Nat Commun. 2022. PMID: 36385050 Free PMC article.
Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
Delfosse V, Huet T, Harrus D, Granell M, Bourguet M, Gardia-Parège C, Chiavarina B, Grimaldi M, Le Mével S, Blanc P, Huang D, Gruszczyk J, Demeneix B, Cianférani S, Fini JB, Balaguer P, Bourguet W. Delfosse V, et al. Among authors: gruszczyk j. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2020551118. doi: 10.1073/pnas.2020551118. Proc Natl Acad Sci U S A. 2021. PMID: 33361153 Free PMC article.
Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH. Gruszczyk J, et al. Nature. 2018 Jul;559(7712):135-139. doi: 10.1038/s41586-018-0249-1. Epub 2018 Jun 27. Nature. 2018. PMID: 29950717
Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells.
Malleret B, El Sahili A, Tay MZ, Carissimo G, Ong ASM, Novera W, Lin J, Suwanarusk R, Kosaisavee V, Chu TTT, Sinha A, Howland SW, Fan Y, Gruszczyk J, Tham WH, Colin Y, Maurer-Stroh S, Snounou G, Ng LFP, Chan JKY, Chacko AM, Lescar J, Chandramohanadas R, Nosten F, Russell B, Rénia L. Malleret B, et al. Among authors: gruszczyk j. Nat Microbiol. 2021 Aug;6(8):991-999. doi: 10.1038/s41564-021-00939-3. Epub 2021 Jul 22. Nat Microbiol. 2021. PMID: 34294905
Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds.
Kwong HS, Paloni M, Grandvuillemin L, Sirounian S, Ancelin A, Lai-Kee-Him J, Grimaldi M, Carivenc C, Lancey C, Ragan TJ, Hesketh EL, Balaguer P, Barducci A, Gruszczyk J, Bourguet W. Kwong HS, et al. Among authors: gruszczyk j. J Mol Biol. 2024 Feb 1;436(3):168411. doi: 10.1016/j.jmb.2023.168411. Epub 2023 Dec 20. J Mol Biol. 2024. PMID: 38135181 Free article.
Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand.
He WQ, Karl S, White MT, Nguitragool W, Monteiro W, Kuehn A, Gruszczyk J, França CT, Sattabongkot J, Lacerda MVG, Tham WH, Mueller I. He WQ, et al. Among authors: gruszczyk j. PLoS Negl Trop Dis. 2019 Aug 19;13(8):e0007596. doi: 10.1371/journal.pntd.0007596. eCollection 2019 Aug. PLoS Negl Trop Dis. 2019. PMID: 31425514 Free PMC article.
Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytes.
Prajapati SK, Borlon C, Rovira-Vallbona E, Gruszczyk J, Menant S, Tham WH, Kattenberg JH, Villasis E, De Meulenaere K, Gamboa D, Vinetz J, Fujita R, Xuan XN, Urbano Ferreira M, Niño CH, Patarroyo MA, Spanakos G, Kestens L, Abbeele JVD, Rosanas-Urgell A. Prajapati SK, et al. Among authors: gruszczyk j. Sci Rep. 2019 Jun 20;9(1):8943. doi: 10.1038/s41598-019-45228-6. Sci Rep. 2019. PMID: 31221984 Free PMC article.
Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites.
Loy DE, Plenderleith LJ, Sundararaman SA, Liu W, Gruszczyk J, Chen YJ, Trimboli S, Learn GH, MacLean OA, Morgan ALK, Li Y, Avitto AN, Giles J, Calvignac-Spencer S, Sachse A, Leendertz FH, Speede S, Ayouba A, Peeters M, Rayner JC, Tham WH, Sharp PM, Hahn BH. Loy DE, et al. Among authors: gruszczyk j. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8450-E8459. doi: 10.1073/pnas.1810053115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30127015 Free PMC article.
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.
Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. Gruszczyk J, et al. Science. 2018 Jan 5;359(6371):48-55. doi: 10.1126/science.aan1078. Science. 2018. PMID: 29302006 Free PMC article.
19 results