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Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation.
Liu Q, Chiu A, Wang LH, An D, Zhong M, Smink AM, de Haan BJ, de Vos P, Keane K, Vegge A, Chen EY, Song W, Liu WF, Flanders J, Rescan C, Grunnet LG, Wang X, Ma M. Liu Q, et al. Among authors: grunnet lg. Nat Commun. 2019 Nov 20;10(1):5262. doi: 10.1038/s41467-019-13238-7. Nat Commun. 2019. PMID: 31748525 Free PMC article.
Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes.
An D, Chiu A, Flanders JA, Song W, Shou D, Lu YC, Grunnet LG, Winkel L, Ingvorsen C, Christophersen NS, Fels JJ, Sand FW, Ji Y, Qi L, Pardo Y, Luo D, Silberstein M, Fan J, Ma M. An D, et al. Among authors: grunnet lg. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E263-E272. doi: 10.1073/pnas.1708806115. Epub 2017 Dec 26. Proc Natl Acad Sci U S A. 2018. PMID: 29279393 Free PMC article.
A Safe, Fibrosis-Mitigating, and Scalable Encapsulation Device Supports Long-Term Function of Insulin-Producing Cells.
Liu W, Flanders JA, Wang LH, Liu Q, Bowers DT, Wang K, Chiu A, Wang X, Ernst AU, Shariati K, Caserto JS, Parker B, Gao D, Plesser MD, Grunnet LG, Rescan C, Pimentel Carletto R, Winkel L, Melero-Martin JM, Ma M. Liu W, et al. Among authors: grunnet lg. Small. 2022 Feb;18(8):e2104899. doi: 10.1002/smll.202104899. Epub 2021 Dec 13. Small. 2022. PMID: 34897997 Free PMC article.
The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.
Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T. Tsonkova VG, et al. Among authors: grunnet lg. Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19. Mol Metab. 2018. PMID: 29307512 Free PMC article.
Cytokines and type 1 diabetes: a numbers game.
Grunnet LG, Mandrup-Poulsen T. Grunnet LG, et al. Diabetes. 2011 Mar;60(3):697-9. doi: 10.2337/db10-1782. Diabetes. 2011. PMID: 21357470 Free PMC article. No abstract available.
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.
Christensen DP, Dahllöf M, Lundh M, Rasmussen DN, Nielsen MD, Billestrup N, Grunnet LG, Mandrup-Poulsen T. Christensen DP, et al. Among authors: grunnet lg. Mol Med. 2011 May-Jun;17(5-6):378-90. doi: 10.2119/molmed.2011.00021. Epub 2011 Jan 25. Mol Med. 2011. PMID: 21274504 Free PMC article. Review.
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, Heller RS, Nielsen AØ, Størling J, Baeyens L, Anker-Kitai L, Qvortrup K, Bouwens L, Efrat S, Aalund M, Andrews NC, Billestrup N, Karlsen AE, Holst B, Pociot F, Mandrup-Poulsen T. Hansen JB, et al. Among authors: grunnet lg. Cell Metab. 2012 Oct 3;16(4):449-61. doi: 10.1016/j.cmet.2012.09.001. Epub 2012 Sep 20. Cell Metab. 2012. PMID: 23000401 Free article.
Oxygen releasing hydrogels for beta cell assisted therapy.
Toftdal MS, Taebnia N, Kadumudi FB, Andresen TL, Frogne T, Winkel L, Grunnet LG, Dolatshahi-Pirouz A. Toftdal MS, et al. Among authors: grunnet lg. Int J Pharm. 2021 Jun 1;602:120595. doi: 10.1016/j.ijpharm.2021.120595. Epub 2021 Apr 20. Int J Pharm. 2021. PMID: 33892060 Free article.
86 results