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Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity.
Castro J, Harrington AM, Lieu T, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller P, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM. Castro J, et al. Among authors: grundy l. JCI Insight. 2019 Oct 17;4(20):e131712. doi: 10.1172/jci.insight.131712. JCI Insight. 2019. PMID: 31536477 Free PMC article.
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.
Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D. Osteen JD, et al. Among authors: grundy l. Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6. Nature. 2016. PMID: 27281198 Free PMC article.
Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.
Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, Vetter I. Inserra MC, et al. Among authors: grundy l. Sci Rep. 2017 Feb 22;7:42810. doi: 10.1038/srep42810. Sci Rep. 2017. PMID: 28225079 Free PMC article.
Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain.
Castro J, Grundy L, Deiteren A, Harrington AM, O'Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM. Castro J, et al. Among authors: grundy l. Br J Pharmacol. 2018 Jun;175(12):2384-2398. doi: 10.1111/bph.14115. Epub 2018 Feb 13. Br J Pharmacol. 2018. PMID: 29194563 Free PMC article.
Contribution of membrane receptor signalling to chronic visceral pain.
Sadeghi M, Erickson A, Castro J, Deiteren A, Harrington AM, Grundy L, Adams DJ, Brierley SM. Sadeghi M, et al. Among authors: grundy l. Int J Biochem Cell Biol. 2018 May;98:10-23. doi: 10.1016/j.biocel.2018.02.017. Epub 2018 Mar 21. Int J Biochem Cell Biol. 2018. PMID: 29477359 Review.
92 results