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Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.
J Med Chem. 2007 Oct 4;50(20):4818-31. doi: 10.1021/jm070314y. Epub 2007 Sep 8.
J Med Chem. 2007.
PMID: 17824679
Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.
Maibaum J, Stutz S, Göschke R, Rigollier P, Yamaguchi Y, Cumin F, Rahuel J, Baum HP, Cohen NC, Schnell CR, Fuhrer W, Gruetter MG, Schilling W, Wood JM.
Maibaum J, et al. Among authors: gruetter mg.
J Med Chem. 2007 Oct 4;50(20):4832-44. doi: 10.1021/jm070316i. Epub 2007 Sep 8.
J Med Chem. 2007.
PMID: 17824680
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A model for the binding of low molecular weight inhibitors to the active site of thrombin.
Allen MC, Cockcroft XL, Gruetter MG, Priestle JP.
Allen MC, et al. Among authors: gruetter mg.
J Comput Aided Mol Des. 1999 Nov;13(6):579-88. doi: 10.1023/a:1008098615891.
J Comput Aided Mol Des. 1999.
PMID: 10584216
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Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor.
Ravn P, Madhurantakam C, Kunze S, Matthews E, Priest C, O'Brien S, Collinson A, Papworth M, Fritsch-Fredin M, Jermutus L, Benthem L, Gruetter M, Jackson RH.
Ravn P, et al.
J Biol Chem. 2013 Jul 5;288(27):19760-72. doi: 10.1074/jbc.M112.426288. Epub 2013 May 20.
J Biol Chem. 2013.
PMID: 23689510
Free PMC article.
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Glutamate 47 in 1-aminocyclopropane-1-carboxylate synthase is a major specificity determinant.
McCarthy DL, Capitani G, Feng L, Gruetter MG, Kirsch JF.
McCarthy DL, et al. Among authors: gruetter mg.
Biochemistry. 2001 Oct 16;40(41):12276-84. doi: 10.1021/bi011050z.
Biochemistry. 2001.
PMID: 11591146
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The human cDNA for a homologue of the plant enzyme 1-aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity.
Koch KA, Capitani G, Gruetter MG, Kirsch JF.
Koch KA, et al. Among authors: gruetter mg.
Gene. 2001 Jul 11;272(1-2):75-84. doi: 10.1016/s0378-1119(01)00533-9.
Gene. 2001.
PMID: 11470512
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