Groves JT - Search Results

1

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC. Sibener LV, et al. Among authors: groves jt. Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017. Cell. 2018. PMID: 30053426 Free PMC article.

2

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

Lillemeier BF, Mörtelmaier MA, Forstner MB, Huppa JB, Groves JT, Davis MM. Lillemeier BF, et al. Among authors: groves jt. Nat Immunol. 2010 Jan;11(1):90-6. doi: 10.1038/ni.1832. Epub 2009 Dec 13. Nat Immunol. 2010. PMID: 20010844 Free PMC article.

3

Altered actin centripetal retrograde flow in physically restricted immunological synapses.

Yu CH, Wu HJ, Kaizuka Y, Vale RD, Groves JT. Yu CH, et al. Among authors: groves jt. PLoS One. 2010 Jul 29;5(7):e11878. doi: 10.1371/journal.pone.0011878. PLoS One. 2010. PMID: 20686692 Free PMC article.

4

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

Manz BN, Jackson BL, Petit RS, Dustin ML, Groves J. Manz BN, et al. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9089-94. doi: 10.1073/pnas.1018771108. Epub 2011 May 16. Proc Natl Acad Sci U S A. 2011. PMID: 21576490 Free PMC article.

5

Signaling clusters in the cell membrane.

Hartman NC, Groves JT. Hartman NC, et al. Among authors: groves jt. Curr Opin Cell Biol. 2011 Aug;23(4):370-6. doi: 10.1016/j.ceb.2011.05.003. Epub 2011 Jun 12. Curr Opin Cell Biol. 2011. PMID: 21665455 Free PMC article. Review.

6

Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells.

Smoligovets AA, Smith AW, Wu HJ, Petit RS, Groves JT. Smoligovets AA, et al. Among authors: groves jt. J Cell Sci. 2012 Feb 1;125(Pt 3):735-42. doi: 10.1242/jcs.092825. J Cell Sci. 2012. PMID: 22389407 Free PMC article.

7

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells.

O'Donoghue GP, Pielak RM, Smoligovets AA, Lin JJ, Groves JT. O'Donoghue GP, et al. Among authors: groves jt. Elife. 2013 Jul 3;2:e00778. doi: 10.7554/eLife.00778. Elife. 2013. PMID: 23840928 Free PMC article.

8

Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.

Pielak RM, O'Donoghue GP, Lin JJ, Alfieri KN, Fay NC, Low-Nam ST, Groves JT. Pielak RM, et al. Among authors: groves jt. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12190-12195. doi: 10.1073/pnas.1613140114. Epub 2017 Oct 30. Proc Natl Acad Sci U S A. 2017. PMID: 29087297 Free PMC article.

9

Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events.

Lin JJY, Low-Nam ST, Alfieri KN, McAffee DB, Fay NC, Groves JT. Lin JJY, et al. Among authors: groves jt. Sci Signal. 2019 Jan 15;12(564):eaat8715. doi: 10.1126/scisignal.aat8715. Sci Signal. 2019. PMID: 30647147 Free PMC article.

10

Membrane Association Transforms an Inert Anti-TCRβ Fab' Ligand into a Potent T Cell Receptor Agonist.

Lin JJ, O'Donoghue GP, Wilhelm KB, Coyle MP, Low-Nam ST, Fay NC, Alfieri KN, Groves JT. Lin JJ, et al. Among authors: groves jt. Biophys J. 2020 Jun 16;118(12):2879-2893. doi: 10.1016/j.bpj.2020.04.018. Epub 2020 Apr 23. Biophys J. 2020. PMID: 32407684 Free PMC article.

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