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Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations.
Frenois-Veyrat G, Gallardo F, Gorgé O, Marcheteau E, Ferraris O, Baidaliuk A, Favier AL, Enfroy C, Holy X, Lourenco J, Khoury R, Nolent F, Grosenbach DW, Hruby DE, Ferrier A, Iseni F, Simon-Loriere E, Tournier JN. Frenois-Veyrat G, et al. Among authors: grosenbach dw. Nat Microbiol. 2022 Dec;7(12):1951-1955. doi: 10.1038/s41564-022-01269-8. Epub 2022 Nov 7. Nat Microbiol. 2022. PMID: 36344621
Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential.
Russo AT, Grosenbach DW, Honeychurch KM, Long PG, Hruby DE. Russo AT, et al. Among authors: grosenbach dw. Expert Rev Anti Infect Ther. 2023 Mar;21(3):235-242. doi: 10.1080/14787210.2023.2170350. Epub 2023 Feb 2. Expert Rev Anti Infect Ther. 2023. PMID: 36728515 Free PMC article.
Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection.
Nguyen BT, Marc A, Suñer C, Marks M, Ubals M, Hernández-Rodríguez Á, Melendez MÁ; Movie Group; Hruby DE, Russo AT, Mentré F, Mitjà O, Grosenbach DW, Guedj J. Nguyen BT, et al. Among authors: grosenbach dw. PLoS Biol. 2023 Dec 21;21(12):e3002249. doi: 10.1371/journal.pbio.3002249. eCollection 2023 Dec. PLoS Biol. 2023. PMID: 38127878 Free PMC article.
Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.
Bell TM, Facemire P, Bearss JJ, Raymond JL, Chapman J, Zeng X, Shamblin JD, Williams JA, Grosenbach DW, Hruby DE, Damon IK, Goff AJ, Mucker EM. Bell TM, et al. Among authors: grosenbach dw. PLoS Pathog. 2024 Feb 22;20(2):e1012007. doi: 10.1371/journal.ppat.1012007. eCollection 2024 Feb. PLoS Pathog. 2024. PMID: 38386661 Free PMC article.
Oral Tecovirimat for the Treatment of Smallpox.
Grosenbach DW, Honeychurch K, Rose EA, Chinsangaram J, Frimm A, Maiti B, Lovejoy C, Meara I, Long P, Hruby DE. Grosenbach DW, et al. N Engl J Med. 2018 Jul 5;379(1):44-53. doi: 10.1056/NEJMoa1705688. N Engl J Med. 2018. PMID: 29972742 Free PMC article. Clinical Trial.
44 results