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The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash.
Nikolaou E, German EL, Blizard A, Howard A, Hitchins L, Chen T, Chadwick J, Pojar S, Mitsi E, Solórzano C, Sunny S, Dunne F, Gritzfeld JF, Adler H, Hinds J, Gould KA, Rylance J, Collins AM, Gordon SB, Ferreira DM. Nikolaou E, et al. Among authors: gritzfeld jf. Sci Rep. 2021 Sep 14;11(1):18279. doi: 10.1038/s41598-021-97807-1. Sci Rep. 2021. PMID: 34521967 Free PMC article.
Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density.
German EL, Solórzano C, Sunny S, Dunne F, Gritzfeld JF, Mitsi E, Nikolaou E, Hyder-Wright AD, Collins AM, Gordon SB, Ferreira DM. German EL, et al. Among authors: gritzfeld jf. Vaccine. 2019 Jul 9;37(30):3953-3956. doi: 10.1016/j.vaccine.2019.05.080. Epub 2019 Jun 5. Vaccine. 2019. PMID: 31176540 Free PMC article. Clinical Trial.
Experimental human pneumococcal carriage.
Gritzfeld JF, Wright AD, Collins AM, Pennington SH, Wright AK, Kadioglu A, Ferreira DM, Gordon SB. Gritzfeld JF, et al. J Vis Exp. 2013 Feb 15;(72):50115. doi: 10.3791/50115. J Vis Exp. 2013. PMID: 23439027 Free PMC article.
Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage.
Pennington SH, Pojar S, Mitsi E, Gritzfeld JF, Nikolaou E, Solórzano C, Owugha JT, Masood Q, Gordon MA, Wright AD, Collins AM, Miyaji EN, Gordon SB, Ferreira DM. Pennington SH, et al. Among authors: gritzfeld jf. Am J Respir Crit Care Med. 2016 Dec 15;194(12):1523-1531. doi: 10.1164/rccm.201512-2467OC. Am J Respir Crit Care Med. 2016. PMID: 27403678 Free PMC article.
Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010-2017.
Adler H, Nikolaou E, Gould K, Hinds J, Collins AM, Connor V, Hales C, Hill H, Hyder-Wright AD, Zaidi SR, German EL, Gritzfeld JF, Mitsi E, Pojar S, Gordon SB, Roberts AP, Rylance J, Ferreira DM. Adler H, et al. Among authors: gritzfeld jf. J Infect Dis. 2019 May 24;219(12):1989-1993. doi: 10.1093/infdis/jiz034. J Infect Dis. 2019. PMID: 30690468 Free PMC article.
Density and duration of experimental human pneumococcal carriage.
Gritzfeld JF, Cremers AJ, Ferwerda G, Ferreira DM, Kadioglu A, Hermans PW, Gordon SB. Gritzfeld JF, et al. Clin Microbiol Infect. 2014 Dec;20(12):O1145-51. doi: 10.1111/1469-0691.12752. Epub 2014 Aug 11. Clin Microbiol Infect. 2014. PMID: 24995531 Free PMC article.
Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage.
Glennie S, Gritzfeld JF, Pennington SH, Garner-Jones M, Coombes N, Hopkins MJ, Vadesilho CF, Miyaji EN, Wang D, Wright AD, Collins AM, Gordon SB, Ferreira DM. Glennie S, et al. Among authors: gritzfeld jf. Mucosal Immunol. 2016 Jan;9(1):56-67. doi: 10.1038/mi.2015.35. Epub 2015 Apr 29. Mucosal Immunol. 2016. PMID: 25921341 Free PMC article. Clinical Trial.
Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage.
Mitsi E, Roche AM, Reiné J, Zangari T, Owugha JT, Pennington SH, Gritzfeld JF, Wright AD, Collins AM, van Selm S, de Jonge MI, Gordon SB, Weiser JN, Ferreira DM. Mitsi E, et al. Among authors: gritzfeld jf. Mucosal Immunol. 2017 Mar;10(2):385-394. doi: 10.1038/mi.2016.71. Epub 2016 Aug 31. Mucosal Immunol. 2017. PMID: 27579859 Free PMC article. Clinical Trial.
Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults.
Ferreira DM, Neill DR, Bangert M, Gritzfeld JF, Green N, Wright AK, Pennington SH, Bricio-Moreno L, Moreno AT, Miyaji EN, Wright AD, Collins AM, Goldblatt D, Kadioglu A, Gordon SB. Ferreira DM, et al. Among authors: gritzfeld jf. Am J Respir Crit Care Med. 2013 Apr 15;187(8):855-64. doi: 10.1164/rccm.201212-2277OC. Am J Respir Crit Care Med. 2013. PMID: 23370916 Free PMC article.
39 results