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Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.
Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G Jr, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. Tayeb-Fligelman E, et al. Among authors: griner sl. Nat Commun. 2023 Apr 25;14(1):2379. doi: 10.1038/s41467-023-37865-3. Nat Commun. 2023. PMID: 37185252 Free PMC article.
De novo designed protein inhibitors of amyloid aggregation and seeding.
Murray KA, Hu CJ, Griner SL, Pan H, Bowler JT, Abskharon R, Rosenberg GM, Cheng X, Seidler PM, Eisenberg DS. Murray KA, et al. Among authors: griner sl. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206240119. doi: 10.1073/pnas.2206240119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969734 Free PMC article.
Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Krotee P, et al. Among authors: griner sl. J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27. J Biol Chem. 2018. PMID: 29282295 Free PMC article.
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS. Tayeb-Fligelman E, et al. bioRxiv [Preprint]. 2021 Mar 18:2021.03.05.434000. doi: 10.1101/2021.03.05.434000. bioRxiv. 2021. PMID: 33688654 Free PMC article. Preprint.
Fabs enable single particle cryoEM studies of small proteins.
Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. Wu S, et al. Among authors: griner sl. Structure. 2012 Apr 4;20(4):582-92. doi: 10.1016/j.str.2012.02.017. Epub 2012 Apr 3. Structure. 2012. PMID: 22483106 Free PMC article.
Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.
Tochowicz A, Dalziel S, Eidam O, O'Connell JD 3rd, Griner S, Finer-Moore JS, Stroud RM. Tochowicz A, et al. J Med Chem. 2013 Jul 11;56(13):5446-55. doi: 10.1021/jm400490e. Epub 2013 Jun 21. J Med Chem. 2013. PMID: 23710599 Free PMC article.
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