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Remodeling of secretory lysosomes during education tunes functional potential in NK cells.
Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ. Goodridge JP, et al. Among authors: grimm c. Nat Commun. 2019 Jan 31;10(1):514. doi: 10.1038/s41467-019-08384-x. Nat Commun. 2019. PMID: 30705279 Free PMC article.
Discovery of lipophilic two-pore channel agonists.
Gerndt S, Krogsaeter E, Patel S, Bracher F, Grimm C. Gerndt S, et al. Among authors: grimm c. FEBS J. 2020 Dec;287(24):5284-5293. doi: 10.1111/febs.15432. Epub 2020 Jun 14. FEBS J. 2020. PMID: 32478984 Free article. Review.
The lysosomotrope GPN mobilises Ca2+ from acidic organelles.
Yuan Y, Kilpatrick BS, Gerndt S, Bracher F, Grimm C, Schapira AH, Patel S. Yuan Y, et al. Among authors: grimm c. J Cell Sci. 2021 Mar 11;134(6):jcs256578. doi: 10.1242/jcs.256578. J Cell Sci. 2021. PMID: 33602742 Free PMC article.
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes.
Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE 2nd, Abrahamian C, Tang R, Keller M, Hartmann J, Rosato AS, Weiden EM, Bracher F, Yule DI, Grimm C, Patel S. Yuan Y, et al. Among authors: grimm c. Nat Commun. 2022 Aug 2;13(1):4481. doi: 10.1038/s41467-022-31959-0. Nat Commun. 2022. PMID: 35918320 Free PMC article.
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.
Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Dang Do AN, Porter FD, Ori A, Sabatini DM, Abu-Remaileh M. Laqtom NN, et al. Among authors: grimm c. Nature. 2022 Sep;609(7929):1005-1011. doi: 10.1038/s41586-022-05221-y. Epub 2022 Sep 21. Nature. 2022. PMID: 36131016 Free PMC article.
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.
Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C. Grimm C, et al. Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699. Nat Commun. 2014. PMID: 25144390 Free article.
737 results