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Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2.
Zangi M, Donald KA, Casals AG, Franson AD, Yu AJ, Marker EM, Woodson ME, Campbell SD, Mottaleb MA, Narayana Hajay Kumar TV, Reddy MS, Raghava Reddy LV, Sadhukhan SK, Griggs DW, Morrison LA, Meyers MJ. Zangi M, et al. Among authors: griggs dw. Eur J Med Chem. 2022 Aug 5;238:114443. doi: 10.1016/j.ejmech.2022.114443. Epub 2022 May 14. Eur J Med Chem. 2022. PMID: 35635945
Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin.
Oboh E, Schubert TJ, Teixeira JE, Stebbins EE, Miller P, Philo E, Thakellapalli H, Campbell SD, Griggs DW, Huston CD, Meyers MJ. Oboh E, et al. Among authors: griggs dw. J Med Chem. 2021 Aug 12;64(15):11729-11745. doi: 10.1021/acs.jmedchem.1c01136. Epub 2021 Aug 3. J Med Chem. 2021. PMID: 34342443 Free PMC article.
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection.
Hasan MM, Stebbins EE, Choy RKM, Gillespie JR, de Hostos EL, Miller P, Mushtaq A, Ranade RM, Teixeira JE, Verlinde CLMJ, Sateriale A, Zhang Z, Osbourn DM, Griggs DW, Fan E, Buckner FS, Huston CD. Hasan MM, et al. Among authors: griggs dw. Antimicrob Agents Chemother. 2021 May 18;65(6):e00023-21. doi: 10.1128/AAC.00023-21. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33753338 Free PMC article.
Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche.
Hirai T, Yang Y, Zenke Y, Li H, Chaudhri VK, De La Cruz Diaz JS, Zhou PY, Nguyen BA, Bartholin L, Workman CJ, Griggs DW, Vignali DAA, Singh H, Masopust D, Kaplan DH. Hirai T, et al. Among authors: griggs dw. Immunity. 2021 Jan 12;54(1):84-98.e5. doi: 10.1016/j.immuni.2020.10.022. Epub 2020 Nov 18. Immunity. 2021. PMID: 33212014 Free PMC article.
Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells.
Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF. Karpova D, et al. Among authors: griggs dw. J Clin Invest. 2019 May 14;129(7):2745-2759. doi: 10.1172/JCI124738. J Clin Invest. 2019. PMID: 31085833 Free PMC article.
41 results