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CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.
Latorre-Leal M, Rodriguez-Rodriguez P, Franchini L, Nikolidakis O, Daniilidou M, Delac L, Varshney MK, Arroyo-García LE, Eroli F, Winblad B, Blennow K, Zetterberg H, Kivipelto M, Pacciarini M, Wang Y, Griffiths WJ, Björkhem I, Matton A, Nalvarte I, Merino-Serrais P, Cedazo-Minguez A, Maioli S. Latorre-Leal M, et al. Among authors: griffiths wj. Sci Adv. 2024 Jan 26;10(4):eadj1354. doi: 10.1126/sciadv.adj1354. Epub 2024 Jan 24. Sci Adv. 2024. PMID: 38266095 Free PMC article.
24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo.
Theofilopoulos S, Abreu de Oliveira WA, Yang S, Yutuc E, Saeed A, Abdel-Khalik J, Ullgren A, Cedazo-Minguez A, Björkhem I, Wang Y, Griffiths WJ, Arenas E. Theofilopoulos S, et al. Among authors: griffiths wj. J Biol Chem. 2019 Mar 15;294(11):4169-4176. doi: 10.1074/jbc.RA118.005639. Epub 2019 Jan 17. J Biol Chem. 2019. PMID: 30655290 Free PMC article.
Oxysterol research: a brief review.
Griffiths WJ, Wang Y. Griffiths WJ, et al. Biochem Soc Trans. 2019 Apr 30;47(2):517-526. doi: 10.1042/BST20180135. Epub 2019 Apr 1. Biochem Soc Trans. 2019. PMID: 30936243 Free PMC article. Review.
Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse.
Crick PJ, Yutuc E, Abdel-Khalik J, Saeed A, Betsholtz C, Genove G, Björkhem I, Wang Y, Griffiths WJ. Crick PJ, et al. Among authors: griffiths wj. J Steroid Biochem Mol Biol. 2019 Dec;195:105475. doi: 10.1016/j.jsbmb.2019.105475. Epub 2019 Sep 18. J Steroid Biochem Mol Biol. 2019. PMID: 31541728 Free PMC article.
Analysis of oxysterol metabolomes.
Griffiths WJ, Wang Y. Griffiths WJ, et al. Biochim Biophys Acta. 2011 Nov;1811(11):784-99. doi: 10.1016/j.bbalip.2011.05.012. Epub 2011 Jun 12. Biochim Biophys Acta. 2011. PMID: 21718802 Review.
Cholesterol metabolism: from lipidomics to immunology.
Griffiths WJ, Wang Y. Griffiths WJ, et al. J Lipid Res. 2022 Feb;63(2):100165. doi: 10.1016/j.jlr.2021.100165. Epub 2021 Dec 22. J Lipid Res. 2022. PMID: 34953867 Free PMC article. Review.
302 results