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Page 1
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.
Dall'Agnese A, Platt JM, Zheng MM, Friesen M, Dall'Agnese G, Blaise AM, Spinelli JB, Henninger JE, Tevonian EN, Hannett NM, Lazaris C, Drescher HK, Bartsch LM, Kilgore HR, Jaenisch R, Griffith LG, Cisse II, Jeppesen JF, Lee TI, Young RA. Dall'Agnese A, et al. Among authors: griffith lg. Nat Commun. 2022 Dec 6;13(1):7522. doi: 10.1038/s41467-022-35176-7. Nat Commun. 2022. PMID: 36473871 Free PMC article.
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Trapecar M, Wogram E, Svoboda D, Communal C, Omer A, Lungjangwa T, Sphabmixay P, Velazquez J, Schneider K, Wright CW, Mildrum S, Hendricks A, Levine S, Muffat J, Lee MJ, Lauffenburger DA, Trumper D, Jaenisch R, Griffith LG. Trapecar M, et al. Among authors: griffith lg. Sci Adv. 2021 Jan 29;7(5):eabd1707. doi: 10.1126/sciadv.abd1707. Print 2021 Jan. Sci Adv. 2021. PMID: 33514545 Free PMC article.
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
Ma H, de Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, Young RA, Jaenisch R. Ma H, et al. Among authors: griffith lg. Cell Stem Cell. 2022 May 5;29(5):795-809.e11. doi: 10.1016/j.stem.2022.03.015. Epub 2022 Apr 21. Cell Stem Cell. 2022. PMID: 35452598 Free PMC article.
Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes.
Jay SM, Kurtagic E, Alvarez LM, de Picciotto S, Sanchez E, Hawkins JF, Prince RN, Guerrero Y, Treasure CL, Lee RT, Griffith LG. Jay SM, et al. Among authors: griffith lg. J Biol Chem. 2011 Aug 5;286(31):27729-40. doi: 10.1074/jbc.M111.221093. Epub 2011 May 26. J Biol Chem. 2011. PMID: 21622572 Free PMC article.
Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.
Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA. Miller MA, et al. Among authors: griffith lg. Cancer Discov. 2016 Apr;6(4):382-99. doi: 10.1158/2159-8290.CD-15-0933. Epub 2016 Mar 16. Cancer Discov. 2016. PMID: 26984351 Free PMC article.
Coculture of primary human colon monolayer with human gut bacteria.
Zhang J, Hernandez-Gordillo V, Trapecar M, Wright C, Taketani M, Schneider K, Chen WLK, Stas E, Breault DT, Carrier RL, Voigt CA, Griffith LG. Zhang J, et al. Among authors: griffith lg. Nat Protoc. 2021 Aug;16(8):3874-3900. doi: 10.1038/s41596-021-00562-w. Epub 2021 Jun 28. Nat Protoc. 2021. PMID: 34183870 Free PMC article.
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA. Miller MA, et al. Among authors: griffith lg. Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2074-83. doi: 10.1073/pnas.1222387110. Epub 2013 May 14. Proc Natl Acad Sci U S A. 2013. PMID: 23674691 Free PMC article.
172 results