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Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.
Divakaran A, Scholtz CR, Zahid H, Lin W, Griffith EC, Lee RE, Chen T, Harki DA, Pomerantz WCK. Divakaran A, et al. Among authors: griffith ec. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627. doi: 10.1021/acsmedchemlett.2c00300. eCollection 2022 Oct 13. ACS Med Chem Lett. 2022. PMID: 36262390 Free PMC article.
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.
Cui H, Divakaran A, Hoell ZJ, Ellingson MO, Scholtz CR, Zahid H, Johnson JA, Griffith EC, Gee CT, Lee AL, Khanal S, Shi K, Aihara H, Shah VH, Lee RE, Harki DA, Pomerantz WCK. Cui H, et al. Among authors: griffith ec. J Med Chem. 2022 Feb 10;65(3):2342-2360. doi: 10.1021/acs.jmedchem.1c01779. Epub 2022 Jan 10. J Med Chem. 2022. PMID: 35007061 Free PMC article.
Mechanistic Insight on the Mode of Action of Colletoic Acid.
Ling T, Miller DJ, Lang WH, Griffith E, Rodriguez-Cortes A, El Ayachi I, Palacios G, Min J, Miranda-Carboni G, Lee RE, Rivas F. Ling T, et al. J Med Chem. 2019 Aug 8;62(15):6925-6940. doi: 10.1021/acs.jmedchem.9b00187. Epub 2019 Jul 24. J Med Chem. 2019. PMID: 31294974 Free PMC article.
Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria.
Wallace MJ, Dharuman S, Fernando DM, Reeve SM, Gee CT, Yao J, Griffith EC, Phelps GA, Wright WC, Elmore JM, Lee RB, Chen T, Lee RE. Wallace MJ, et al. Among authors: griffith ec. ACS Infect Dis. 2020 Mar 13;6(3):467-478. doi: 10.1021/acsinfecdis.9b00406. Epub 2020 Jan 13. ACS Infect Dis. 2020. PMID: 31887254 Free PMC article.
The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori That Act through Inhibition of the Respiratory Complex I.
Mugengana AK, Vita NA, Brown Gandt A, Moran K, Agyapong G, Sharma LK, Griffith EC, Liu J, Yang L, Gavrish E, Hevener KE, LaFleur MD, Lee RE. Mugengana AK, et al. Among authors: griffith ec. ACS Infect Dis. 2021 May 14;7(5):1044-1058. doi: 10.1021/acsinfecdis.0c00300. Epub 2021 Jan 20. ACS Infect Dis. 2021. PMID: 33471519 Free PMC article.
77 results