Greggio E - Search Results

1

The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.

Cogo S, Ho FY, Tosoni E, Tomkins JE, Tessari I, Iannotta L, Montine TJ, Manzoni C, Lewis PA, Bubacco L, Chartier Harlin MC, Taymans JM, Kortholt A, Nichols J, Cendron L, Civiero L, Greggio E. Cogo S, et al. Among authors: greggio e. Brain Res. 2022 Mar 1;1778:147781. doi: 10.1016/j.brainres.2022.147781. Epub 2022 Jan 10. Brain Res. 2022. PMID: 35016853

2

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease.

Greggio E, Bergantino E, Carter D, Ahmad R, Costin GE, Hearing VJ, Clarimon J, Singleton A, Eerola J, Hellström O, Tienari PJ, Miller DW, Beilina A, Bubacco L, Cookson MR. Greggio E, et al. J Neurochem. 2005 Apr;93(1):246-56. doi: 10.1111/j.1471-4159.2005.03019.x. J Neurochem. 2005. PMID: 15773923 Free article.

3

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.

Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR. Greggio E, et al. Neurobiol Dis. 2006 Aug;23(2):329-41. doi: 10.1016/j.nbd.2006.04.001. Epub 2006 Jun 5. Neurobiol Dis. 2006. PMID: 16750377

4

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, Ding J, Beilina A, Baker AK, Cookson MR. Greggio E, et al. J Neurochem. 2007 Jul;102(1):93-102. doi: 10.1111/j.1471-4159.2007.04523.x. Epub 2007 Mar 29. J Neurochem. 2007. PMID: 17394548 Free article.

5

The R1441C mutation of LRRK2 disrupts GTP hydrolysis.

Lewis PA, Greggio E, Beilina A, Jain S, Baker A, Cookson MR. Lewis PA, et al. Among authors: greggio e. Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71. doi: 10.1016/j.bbrc.2007.04.006. Epub 2007 Apr 10. Biochem Biophys Res Commun. 2007. PMID: 17442267 Free PMC article.

6

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.

Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR. Deng J, et al. Among authors: greggio e. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1499-504. doi: 10.1073/pnas.0709098105. Epub 2008 Jan 29. Proc Natl Acad Sci U S A. 2008. PMID: 18230735 Free PMC article.

7

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.

Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniëls V, Lewis P, Jain S, Ding J, Syed A, Thomas KJ, Baekelandt V, Cookson MR. Greggio E, et al. J Biol Chem. 2008 Jun 13;283(24):16906-14. doi: 10.1074/jbc.M708718200. Epub 2008 Apr 8. J Biol Chem. 2008. PMID: 18397888 Free PMC article.

8

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.

Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR. Greggio E, et al. Biochem Biophys Res Commun. 2009 Nov 20;389(3):449-54. doi: 10.1016/j.bbrc.2009.08.163. Epub 2009 Sep 3. Biochem Biophys Res Commun. 2009. PMID: 19733152 Free PMC article.

9

The R1441C mutation alters the folding properties of the ROC domain of LRRK2.

Li Y, Dunn L, Greggio E, Krumm B, Jackson GS, Cookson MR, Lewis PA, Deng J. Li Y, et al. Among authors: greggio e. Biochim Biophys Acta. 2009 Dec;1792(12):1194-7. doi: 10.1016/j.bbadis.2009.09.010. Epub 2009 Sep 23. Biochim Biophys Acta. 2009. PMID: 19781641 Free PMC article.

10

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.

Kumar A, Greggio E, Beilina A, Kaganovich A, Chan D, Taymans JM, Wolozin B, Cookson MR. Kumar A, et al. Among authors: greggio e. PLoS One. 2010 Jan 15;5(1):e8730. doi: 10.1371/journal.pone.0008730. PLoS One. 2010. PMID: 20090955 Free PMC article.

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