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Monomeric α-synuclein activates the plasma membrane calcium pump.
Kowalski A, Betzer C, Larsen ST, Gregersen E, Newcombe EA, Bermejo MC, Bendtsen VW, Diemer J, Ernstsen CV, Jain S, Bou AE, Langkilde AE, Nejsum LN, Klipp E, Edwards R, Kragelund BB, Jensen PH, Nissen P. Kowalski A, et al. Among authors: gregersen e. EMBO J. 2023 Dec 1;42(23):e111122. doi: 10.15252/embj.2022111122. Epub 2023 Nov 2. EMBO J. 2023. PMID: 37916890 Free PMC article.
Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.
Betzer C, Lassen LB, Olsen A, Kofoed RH, Reimer L, Gregersen E, Zheng J, Calì T, Gai WP, Chen T, Moeller A, Brini M, Fu Y, Halliday G, Brudek T, Aznar S, Pakkenberg B, Andersen JP, Jensen PH. Betzer C, et al. Among authors: gregersen e. EMBO Rep. 2018 May;19(5):e44617. doi: 10.15252/embr.201744617. Epub 2018 Mar 29. EMBO Rep. 2018. PMID: 29599149 Free PMC article.
Stabilization of α-synuclein oligomers using formaldehyde.
Ruesink H, Reimer L, Gregersen E, Moeller A, Betzer C, Jensen PH. Ruesink H, et al. Among authors: gregersen e. PLoS One. 2019 Oct 11;14(10):e0216764. doi: 10.1371/journal.pone.0216764. eCollection 2019. PLoS One. 2019. PMID: 31603909 Free PMC article.
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.
Ferreira N, Gram H, Sorrentino ZA, Gregersen E, Schmidt SI, Reimer L, Betzer C, Perez-Gozalbo C, Beltoja M, Nagaraj M, Wang J, Nowak JS, Dong M, Willén K, Cholak E, Bjerregaard-Andersen K, Mendez N, Rabadia P, Shahnawaz M, Soto C, Otzen DE, Akbey Ü, Meyer M, Giasson BI, Romero-Ramos M, Jensen PH. Ferreira N, et al. Among authors: gregersen e. Acta Neuropathol. 2021 Jul;142(1):87-115. doi: 10.1007/s00401-021-02316-0. Epub 2021 May 12. Acta Neuropathol. 2021. PMID: 33978813 Free PMC article.
Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Vecchio LM, Sullivan P, Dunn AR, Bermejo MK, Fu R, Masoud ST, Gregersen E, Urs NM, Nazari R, Jensen PH, Ramsey A, Goldstein DS, Miller GW, Salahpour A. Vecchio LM, et al. Among authors: gregersen e. J Neurochem. 2021 Aug;158(4):960-979. doi: 10.1111/jnc.15432. Epub 2021 Jun 12. J Neurochem. 2021. PMID: 33991113 Free PMC article.
88 results