Gray K - Search Results

1

Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli.

Sheth PR, Ramanathan L, Ranchod A, Basso AD, Barrett D, Zhao J, Gray K, Liu YH, Zhang R, Le HV. Sheth PR, et al. Among authors: gray k. Arch Biochem Biophys. 2010 Nov 15;503(2):191-201. doi: 10.1016/j.abb.2010.08.004. Epub 2010 Aug 10. Arch Biochem Biophys. 2010. PMID: 20699085

2

Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.

Sheth PR, Shipps GW Jr, Seghezzi W, Smith CK, Chuang CC, Sanden D, Basso AD, Vilenchik L, Gray K, Annis DA, Nickbarg E, Ma Y, Lahue B, Herbst R, Le HV. Sheth PR, et al. Among authors: gray k. Biochemistry. 2010 Sep 28;49(38):8350-8. doi: 10.1021/bi1005283. Biochemistry. 2010. PMID: 20718440

3

Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein.

Sheth PR, Basso A, Duca JS, Lesburg CA, Ogas P, Gray K, Nale L, Mannarino AF, Prongay AJ, Le HV. Sheth PR, et al. Among authors: gray k. Biochemistry. 2009 Nov 24;48(46):11045-55. doi: 10.1021/bi900946r. Biochemistry. 2009. PMID: 19824700

4

Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors.

Meng Z, Kulkarni BA, Kerekes AD, Mandal AK, Esposite SJ, Belanger DB, Reddy PA, Basso AD, Tevar S, Gray K, Jones J, Smith EB, Doll RJ, Siddiqui MA. Meng Z, et al. Among authors: gray k. Bioorg Med Chem Lett. 2011 Jan 1;21(1):592-8. doi: 10.1016/j.bmcl.2010.10.008. Epub 2010 Oct 12. Bioorg Med Chem Lett. 2011. PMID: 21075632

5

Structural basis of CX-4945 binding to human protein kinase CK2.

Ferguson AD, Sheth PR, Basso AD, Paliwal S, Gray K, Fischmann TO, Le HV. Ferguson AD, et al. Among authors: gray k. FEBS Lett. 2011 Jan 3;585(1):104-10. doi: 10.1016/j.febslet.2010.11.019. Epub 2010 Nov 18. FEBS Lett. 2011. PMID: 21093442 Free article.

6

Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

Belanger DB, Curran PJ, Hruza A, Voigt J, Meng Z, Mandal AK, Siddiqui MA, Basso AD, Gray K. Belanger DB, et al. Among authors: gray k. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5170-4. doi: 10.1016/j.bmcl.2010.07.008. Epub 2010 Jul 8. Bioorg Med Chem Lett. 2010. PMID: 20674350

7

Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

Belanger DB, Williams MJ, Curran PJ, Mandal AK, Meng Z, Rainka MP, Yu T, Shih NY, Siddiqui MA, Liu M, Tevar S, Lee S, Liang L, Gray K, Yaremko B, Jones J, Smith EB, Prelusky DB, Basso AD. Belanger DB, et al. Among authors: gray k. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43. doi: 10.1016/j.bmcl.2010.08.140. Epub 2010 Sep 18. Bioorg Med Chem Lett. 2010. PMID: 20855207

8

Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.

Voss ME, Rainka MP, Fleming M, Peterson LH, Belanger DB, Siddiqui MA, Hruza A, Voigt J, Gray K, Basso AD. Voss ME, et al. Among authors: gray k. Bioorg Med Chem Lett. 2012 May 15;22(10):3544-9. doi: 10.1016/j.bmcl.2012.03.051. Epub 2012 Mar 21. Bioorg Med Chem Lett. 2012. PMID: 22503250

9

SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors.

Basso AD, Liu M, Gray K, Tevar S, Lee S, Liang L, Ponery A, Smith EB, Monsma FJ Jr, Yu T, Zhang Y, Kerekes AD, Esposite S, Xiao Y, Tagat JR, Hicklin DJ, Kirschmeier P. Basso AD, et al. Among authors: gray k. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33. doi: 10.1007/s00280-011-1568-1. Epub 2011 Feb 5. Cancer Chemother Pharmacol. 2011. PMID: 21298383

10

Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure.

Kerekes AD, Esposite SJ, Doll RJ, Tagat JR, Yu T, Xiao Y, Zhang Y, Prelusky DB, Tevar S, Gray K, Terracina GA, Lee S, Jones J, Liu M, Basso AD, Smith EB. Kerekes AD, et al. Among authors: gray k. J Med Chem. 2011 Jan 13;54(1):201-10. doi: 10.1021/jm1010995. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128646

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