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203 results

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A living ex vivo platform for functional, personalized brain cancer diagnosis.
Mann B, Zhang X, Bell N, Adefolaju A, Thang M, Dasari R, Kanchi K, Valdivia A, Yang Y, Buckley A, Lettry V, Quinsey C, Rauf Y, Kram D, Cassidy N, Vaziri C, Corcoran DL, Rego S, Jiang Y, Graves LM, Dunn D, Floyd S, Baldwin A, Hingtgen S, Satterlee AB. Mann B, et al. Among authors: graves lm. Cell Rep Med. 2023 Jun 20;4(6):101042. doi: 10.1016/j.xcrm.2023.101042. Epub 2023 May 15. Cell Rep Med. 2023. PMID: 37192626 Free PMC article.
Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.
Fennell EMJ, Aponte-Collazo LJ, Pathmasiri W, Rushing BR, Barker NK, Partridge MC, Li YY, White CA, Greer YE, Herring LE, Lipkowitz S, Sumner SCJ, Iwanowicz EJ, Graves LM. Fennell EMJ, et al. Among authors: graves lm. Front Pharmacol. 2023 Mar 31;14:1136317. doi: 10.3389/fphar.2023.1136317. eCollection 2023. Front Pharmacol. 2023. PMID: 37063293 Free PMC article.
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mabanglo MF, Wong KS, Barghash MM, Leung E, Chuang SHW, Ardalan A, Majaesic EM, Wong CJ, Zhang S, Lang H, Karanewsky DS, Iwanowicz AA, Graves LM, Iwanowicz EJ, Gingras AC, Houry WA. Mabanglo MF, et al. Among authors: graves lm. Structure. 2023 Feb 2;31(2):185-200.e10. doi: 10.1016/j.str.2022.12.002. Epub 2022 Dec 30. Structure. 2023. PMID: 36586405 Free PMC article.
Metatranscriptomics analysis reveals a novel transcriptional and translational landscape during Middle East respiratory syndrome coronavirus infection.
Fritch EJ, Sanders W, Sims AC, Herring LE, Barker NK, Schepmoes AA, Weitz KK, Texier JR, Dittmer DP, Graves LM, Smith RD, Waters KM, Moorman NJ, Baric RS, Graham RL. Fritch EJ, et al. Among authors: graves lm. iScience. 2023 May 2;26(6):106780. doi: 10.1016/j.isci.2023.106780. eCollection 2023 Jun 16. iScience. 2023. PMID: 37193127 Free PMC article.
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.
Fritch EJ, Mordant AL, Gilbert TSK, Wells CI, Yang X, Barker NK, Madden EA, Dinnon KH 3rd, Hou YJ, Tse LV, Castillo IN, Sims AC, Moorman NJ, Lakshmanane P, Willson TM, Herring LE, Graves LM, Baric RS. Fritch EJ, et al. Among authors: graves lm. J Proteome Res. 2023 Oct 6;22(10):3159-3177. doi: 10.1021/acs.jproteome.3c00182. Epub 2023 Aug 27. J Proteome Res. 2023. PMID: 37634194
Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis.
Greer YE, Hernandez L, Fennell EMJ, Kundu M, Voeller D, Chari R, Gilbert SF, Gilbert TSK, Ratnayake S, Tang B, Hafner M, Chen Q, Meerzaman D, Iwanowicz E, Annunziata CM, Graves LM, Lipkowitz S. Greer YE, et al. Among authors: graves lm. Cancer Res Commun. 2022 Oct 10;2(10):1144-1161. doi: 10.1158/2767-9764.CRC-22-0142. Cancer Res Commun. 2022. PMID: 36388465 Free PMC article.
Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization.
Romano LEL, Aw WY, Hixson KM, Novoselova TV, Havener TM, Howell S, Taylor-Blake B, Hall CL, Xing L, Beri J, Nethisinghe S, Perna L, Hatimy A, Altadonna GC, Graves LM, Herring LE, Hickey AJ, Thalassinos K, Chapple JP, Wolter JM. Romano LEL, et al. Among authors: graves lm. Cell Rep. 2022 Nov 1;41(5):111580. doi: 10.1016/j.celrep.2022.111580. Cell Rep. 2022. PMID: 36323248 Free PMC article.
Cytomegalovirus US28 regulates cellular EphA2 to maintain viral latency.
Wass AB, Krishna BA, Herring LE, Gilbert TSK, Nukui M, Groves IJ, Dooley AL, Kulp KH, Matthews SM, Rotroff DM, Graves LM, O'Connor CM. Wass AB, et al. Among authors: graves lm. Sci Adv. 2022 Oct 28;8(43):eadd1168. doi: 10.1126/sciadv.add1168. Epub 2022 Oct 26. Sci Adv. 2022. PMID: 36288299 Free PMC article.
203 results