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R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts.
Liu ZS, Sinha S, Bannister M, Song A, Arriaga-Gomez E, McKeeken AJ, Bonner EA, Hanson BK, Sarchi M, Takashima K, Zong D, Corral VM, Nguyen E, Yoo J, Chiraphapphaiboon W, Leibson C, McMahon MC, Rai S, Swisher EM, Sachs Z, Chatla S, Stirewalt DL, Deeg HJ, Skorski T, Papapetrou EP, Walter MJ, Graubert TA, Doulatov S, Lee SC, Nguyen HD. Liu ZS, et al. Among authors: graubert ta. Cancer Res. 2024 Feb 15;84(4):577-597. doi: 10.1158/0008-5472.CAN-23-3239. Cancer Res. 2024. PMID: 37967363
Splicing factor gene mutations in hematologic malignancies.
Saez B, Walter MJ, Graubert TA. Saez B, et al. Among authors: graubert ta. Blood. 2017 Mar 9;129(10):1260-1269. doi: 10.1182/blood-2016-10-692400. Epub 2016 Dec 9. Blood. 2017. PMID: 27940478 Free PMC article. Review.
Genetics of myelodysplastic syndromes: new insights.
Graubert T, Walter MJ. Graubert T, et al. Hematology Am Soc Hematol Educ Program. 2011;2011:543-9. doi: 10.1182/asheducation-2011.1.543. Hematology Am Soc Hematol Educ Program. 2011. PMID: 22160087 Review.
Targeting R-loop-associated ATR response in myelodysplastic syndrome.
Nguyen HD, Zou L, Graubert TA. Nguyen HD, et al. Among authors: graubert ta. Oncotarget. 2019 Apr 5;10(27):2581-2582. doi: 10.18632/oncotarget.26851. eCollection 2019 Apr 5. Oncotarget. 2019. PMID: 31080550 Free PMC article. No abstract available.
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.
Shirai CL, Ley JN, White BS, Kim S, Tibbitts J, Shao J, Ndonwi M, Wadugu B, Duncavage EJ, Okeyo-Owuor T, Liu T, Griffith M, McGrath S, Magrini V, Fulton RS, Fronick C, O'Laughlin M, Graubert TA, Walter MJ. Shirai CL, et al. Among authors: graubert ta. Cancer Cell. 2015 May 11;27(5):631-43. doi: 10.1016/j.ccell.2015.04.008. Cancer Cell. 2015. PMID: 25965570 Free PMC article.
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex.
Chatrikhi R, Feeney CF, Pulvino MJ, Alachouzos G, MacRae AJ, Falls Z, Rai S, Brennessel WW, Jenkins JL, Walter MJ, Graubert TA, Samudrala R, Jurica MS, Frontier AJ, Kielkopf CL. Chatrikhi R, et al. Among authors: graubert ta. Cell Chem Biol. 2021 Aug 19;28(8):1145-1157.e6. doi: 10.1016/j.chembiol.2021.02.007. Epub 2021 Mar 8. Cell Chem Biol. 2021. PMID: 33689684 Free PMC article.
108 results