Grassie M - Search Results

1

Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.

Brown AR, Bosies M, Cameron H, Clark J, Cowley A, Craighead M, Elmore MA, Firth A, Goodwin R, Goutcher S, Grant E, Grassie M, Grove SJ, Hamilton NM, Hampson H, Hillier A, Ho KK, Kiczun M, Kingsbury C, Kultgen SG, Littlewood PT, Lusher SJ, Macdonald S, McIntosh L, McIntyre T, Mistry A, Morphy JR, Nimz O, Ohlmeyer M, Pick J, Rankovic Z, Sherborne B, Smith A, Speake M, Spinks G, Thomson F, Watson L, Weston M. Brown AR, et al. Among authors: grassie m. Bioorg Med Chem Lett. 2011 Jan 1;21(1):137-40. doi: 10.1016/j.bmcl.2010.11.054. Epub 2010 Nov 16. Bioorg Med Chem Lett. 2011. PMID: 21129964

2

Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release.

Spiga F, Harrison LR, Wood SA, MacSweeney CP, Thomson FJ, Craighead M, Grassie M, Lightman SL. Spiga F, et al. Among authors: grassie m. J Endocrinol. 2008 Feb;196(2):323-30. doi: 10.1677/JOE-07-0503. J Endocrinol. 2008. PMID: 18252955

3

Effect of the glucocorticoid receptor antagonist Org 34850 on basal and stress-induced corticosterone secretion.

Spiga F, Harrison LR, Wood SA, Atkinson HC, MacSweeney CP, Thomson F, Craighead M, Grassie M, Lightman SL. Spiga F, et al. Among authors: grassie m. J Neuroendocrinol. 2007 Nov;19(11):891-900. doi: 10.1111/j.1365-2826.2007.01605.x. J Neuroendocrinol. 2007. PMID: 17927667

4

Acute oral dexamethasone administration reduces levels of orphan GPCR glucocorticoid-induced receptor (GIR) mRNA in rodent brain: potential role in HPA-axis function.

Adams F, Grassie M, Shahid M, Hill DR, Henry B. Adams F, et al. Among authors: grassie m. Brain Res Mol Brain Res. 2003 Sep 10;117(1):39-46. doi: 10.1016/s0169-328x(03)00280-8. Brain Res Mol Brain Res. 2003. PMID: 14499479

5

Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.

Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ. Thomson PA, et al. Among authors: grassie ma. Mol Psychiatry. 2005 May;10(5):470-8. doi: 10.1038/sj.mp.4001593. Mol Psychiatry. 2005. PMID: 15452587 Clinical Trial.

6

Thyrotropin-releasing hormone-induced subcellular redistribution and down-regulation of G11alpha: analysis of agonist regulation of coexpressed G11alpha species variants.

Svoboda P, Kim GD, Grassie MA, Eidne KA, Milligan G. Svoboda P, et al. Among authors: grassie ma. Mol Pharmacol. 1996 Apr;49(4):646-55. Mol Pharmacol. 1996. PMID: 8609892

7

Mechanisms of agonist-induced G-protein elimination.

Milligan G, Wise A, MacEwan DJ, Grassie MA, Kennedy FR, Lee TW, Adie EJ, Kim GD, McCallum JF, Burt A, et al. Milligan G, et al. Among authors: grassie ma. Biochem Soc Trans. 1995 Feb;23(1):166-70. doi: 10.1042/bst0230166. Biochem Soc Trans. 1995. PMID: 7758721 Review. No abstract available.

8

Agonist-mediated turnover of G-protein alpha-subunit palmitoyl groups. Role in membrane insertion.

Grassie MA, Milligan G. Grassie MA, et al. Methods Mol Biol. 1998;88:241-8. doi: 10.1385/0-89603-487-9:241. Methods Mol Biol. 1998. PMID: 9664310 No abstract available.

9

Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and alpha 2C10 adrenoceptor-transfected Rat 1 fibroblasts.

Carr C, Grassie M, Milligan G. Carr C, et al. Among authors: grassie m. Biochem J. 1994 Mar 1;298 ( Pt 2)(Pt 2):493-7. doi: 10.1042/bj2980493. Biochem J. 1994. PMID: 8135760 Free PMC article.

10

The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane.

McCallum JF, Wise A, Grassie MA, Magee AI, Guzzi F, Parenti M, Milligan G. McCallum JF, et al. Among authors: grassie ma. Biochem J. 1995 Sep 15;310 ( Pt 3)(Pt 3):1021-7. doi: 10.1042/bj3101021. Biochem J. 1995. PMID: 7575398 Free PMC article.

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