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Phosphoproteomics of patient-derived xenografts identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer.
Beekhof R, Bertotti A, Böttger F, Vurchio V, Cottino F, Zanella ER, Migliardi G, Viviani M, Grassi E, Lupo B, Henneman AA, Knol JC, Pham TV, de Goeij-de Haas R, Piersma SR, Labots M, Verheul HMW, Trusolino L, Jimenez CR. Beekhof R, et al. Among authors: grassi e. Sci Transl Med. 2023 Aug 16;15(709):eabm3687. doi: 10.1126/scitranslmed.abm3687. Epub 2023 Aug 16. Sci Transl Med. 2023. PMID: 37585503 Free article.
Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype.
Lupo B, Sassi F, Pinnelli M, Galimi F, Zanella ER, Vurchio V, Migliardi G, Gagliardi PA, Puliafito A, Manganaro D, Luraghi P, Kragh M, Pedersen MW, Horak ID, Boccaccio C, Medico E, Primo L, Nichol D, Spiteri I, Heide T, Vatsiou A, Graham TA, Élez E, Argiles G, Nuciforo P, Sottoriva A, Dienstmann R, Pasini D, Grassi E, Isella C, Bertotti A, Trusolino L. Lupo B, et al. Among authors: grassi e. Sci Transl Med. 2020 Aug 5;12(555):eaax8313. doi: 10.1126/scitranslmed.aax8313. Sci Transl Med. 2020. PMID: 32759276 Free article.
Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin.
Tedesco M, Giannese F, Lazarević D, Giansanti V, Rosano D, Monzani S, Catalano I, Grassi E, Zanella ER, Botrugno OA, Morelli L, Panina Bordignon P, Caravagna G, Bertotti A, Martino G, Aldrighetti L, Pasqualato S, Trusolino L, Cittaro D, Tonon G. Tedesco M, et al. Among authors: grassi e. Nat Biotechnol. 2022 Feb;40(2):235-244. doi: 10.1038/s41587-021-01031-1. Epub 2021 Oct 11. Nat Biotechnol. 2022. PMID: 34635836
Towards precision oncology with patient-derived xenografts.
Zanella ER, Grassi E, Trusolino L. Zanella ER, et al. Among authors: grassi e. Nat Rev Clin Oncol. 2022 Nov;19(11):719-732. doi: 10.1038/s41571-022-00682-6. Epub 2022 Sep 23. Nat Rev Clin Oncol. 2022. PMID: 36151307 Review.
Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer.
Leto SM, Ferri M, Sassi F, Zanella ER, Cottino F, Vurchio V, Catalano I, Ferrero A, Zingaretti CC, Marchiò C, Grassi E, Trusolino L, Bertotti A. Leto SM, et al. Among authors: grassi e. Clin Cancer Res. 2023 Mar 14;29(6):1102-1113. doi: 10.1158/1078-0432.CCR-22-2550. Clin Cancer Res. 2023. PMID: 36622698 Free PMC article.
Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT).
Falcinelli M, Dell'Omo G, Grassi E, Mariella E, Leto SM, Scardellato S, Lorenzato A, Arena S, Bertotti A, Trusolino L, Bardelli A, d'Adda di Fagagna F. Falcinelli M, et al. Among authors: grassi e. Cell Death Dis. 2023 Feb 9;14(2):96. doi: 10.1038/s41419-023-05640-3. Cell Death Dis. 2023. PMID: 36759506 Free PMC article.
276 results