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γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
Hu MD, Golovchenko NB, Burns GL, Nair PM, Kelly TJ 4th, Agos J, Irani MZ, Soh WS, Zeglinski MR, Lemenze A, Bonder EM, Sandrock I, Prinz I, Granville DJ, Keely S, Watson AJM, Edelblum KL. Hu MD, et al. Among authors: granville dj. Gastroenterology. 2022 Mar;162(3):877-889.e7. doi: 10.1053/j.gastro.2021.11.028. Epub 2021 Dec 1. Gastroenterology. 2022. PMID: 34861219 Free PMC article.
Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture.
Shen Y, Russo V, Zeglinski MR, Sellers SL, Wu Z, Oram C, Santacruz S, Merkulova Y, Turner C, Tauh K, Zhao H, Bozin T, Bohunek L, Zeng H, Seidman MA, Bleackley RC, McManus BM, Ruoslahti E, Järvinen TAH, Granville DJ. Shen Y, et al. Among authors: granville dj. Sci Rep. 2017 Nov 20;7(1):15857. doi: 10.1038/s41598-017-16194-8. Sci Rep. 2017. PMID: 29158532 Free PMC article.
Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing.
Shen Y, Zeglinski MR, Turner CT, Raithatha SA, Wu Z, Russo V, Oram C, Hiroyasu S, Nabai L, Zhao H, Bozin T, Westendorf K, Kopko I, Huang R, Arns S, Tan J, Zeng H, Boey A, Liggins R, Jaquith J, Cameron DR, Papp A, Granville DJ. Shen Y, et al. Among authors: granville dj. Exp Mol Med. 2018 May 30;50(5):1-11. doi: 10.1038/s12276-018-0095-0. Exp Mol Med. 2018. PMID: 29849046 Free PMC article.
Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction.
Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, Franzke CW, Overall CM, Granville DJ. Russo V, et al. Among authors: granville dj. Sci Rep. 2018 Jun 26;8(1):9690. doi: 10.1038/s41598-018-28070-0. Sci Rep. 2018. PMID: 29946113 Free PMC article.
Granzymes in cardiovascular injury and disease.
Zeglinski MR, Granville DJ. Zeglinski MR, et al. Among authors: granville dj. Cell Signal. 2020 Dec;76:109804. doi: 10.1016/j.cellsig.2020.109804. Epub 2020 Oct 7. Cell Signal. 2020. PMID: 33035645 Review.
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Hiroyasu S, Zeglinski MR, Zhao H, Pawluk MA, Turner CT, Kasprick A, Tateishi C, Nishie W, Burleigh A, Lennox PA, Van Laeken N, Carr NJ, Petersen F, Crawford RI, Shimizu H, Tsuruta D, Ludwig RJ, Granville DJ. Hiroyasu S, et al. Among authors: granville dj. Nat Commun. 2021 Jan 12;12(1):302. doi: 10.1038/s41467-020-20604-3. Nat Commun. 2021. PMID: 33436591 Free PMC article.
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