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Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
Liu L, Malagu K, Haughan AF, Khetarpal V, Stott AJ, Esmieu W, Vater HD, Webster SJ, Van de Poël AJ, Clissold C, Cosgrove B, Sutton B, Spencer JA, Breccia P, Gancia E, Bonomo S, Ladduwahetty T, Lazari O, Patel H, Atton HC, Clifton S, Mota DM, Magnani D, O'Neill A, Stebbeds M, Macabuag N, Todd D, Herva ME, Mitchell P, Visser M, Compte Sancerni S, Grand Moursel L, da Silva M, Kritikou E, Heikkinen TT, Bolkvadze T, Fodale V, Spadafora D, Daldin M, Bresciani A, Mangette JE, Doherty EM, Lee MR, Herbst T, Monteagudo E, Macdonald D, Plotnikov NV, Chambers M, McAllister G, Muňoz-Sanjuan I, Dominguez C. Liu L, et al. Among authors: grand moursel l. J Med Chem. 2023 Sep 28;66(18):13205-13246. doi: 10.1021/acs.jmedchem.3c01173. Epub 2023 Sep 15. J Med Chem. 2023. PMID: 37712656
CRISPRing future medicines.
Grand Moursel L, Visser M, Servant G, Durmus S, Zuurmond AM. Grand Moursel L, et al. Expert Opin Drug Discov. 2021 Apr;16(4):463-473. doi: 10.1080/17460441.2021.1850687. Epub 2021 Jan 3. Expert Opin Drug Discov. 2021. PMID: 33322954 Review.
Brain Transcriptomic Analysis of Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type.
Grand Moursel L, van Roon-Mom WMC, Kiełbasa SM, Mei H, Buermans HPJ, van der Graaf LM, Hettne KM, de Meijer EJ, van Duinen SG, Laros JFJ, van Buchem MA, 't Hoen PAC, van der Maarel SM, van der Weerd L. Grand Moursel L, et al. Front Aging Neurosci. 2018 Apr 13;10:102. doi: 10.3389/fnagi.2018.00102. eCollection 2018. Front Aging Neurosci. 2018. PMID: 29706885 Free PMC article.
Human-brain ferritin studied by muon spin rotation: a pilot study.
Bossoni L, Grand Moursel L, Bulk M, Simon BG, Webb A, van der Weerd L, Huber M, Carretta P, Lascialfari A, Oosterkamp TH. Bossoni L, et al. Among authors: grand moursel l. J Phys Condens Matter. 2017 Oct 18;29(41):415801. doi: 10.1088/1361-648X/aa80b3. Epub 2017 Sep 5. J Phys Condens Matter. 2017. PMID: 28872048
Dysferlin regulates cell adhesion in human monocytes.
de Morrée A, Flix B, Bagaric I, Wang J, van den Boogaard M, Grand Moursel L, Frants RR, Illa I, Gallardo E, Toes R, van der Maarel SM. de Morrée A, et al. Among authors: grand moursel l. J Biol Chem. 2013 May 17;288(20):14147-14157. doi: 10.1074/jbc.M112.448589. Epub 2013 Apr 4. J Biol Chem. 2013. PMID: 23558685 Free PMC article.
Self-regulated alternative splicing at the AHNAK locus.
de Morrée A, Droog M, Grand Moursel L, Bisschop IJ, Impagliazzo A, Frants RR, Klooster R, van der Maarel SM. de Morrée A, et al. Among authors: grand moursel l. FASEB J. 2012 Jan;26(1):93-103. doi: 10.1096/fj.11-187971. Epub 2011 Sep 22. FASEB J. 2012. PMID: 21940993