Graham MJ - Search Results

1

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice.

Prakash TP, Graham MJ, Yu J, Carty R, Low A, Chappell A, Schmidt K, Zhao C, Aghajan M, Murray HF, Riney S, Booten SL, Murray SF, Gaus H, Crosby J, Lima WF, Guo S, Monia BP, Swayze EE, Seth PP. Prakash TP, et al. Among authors: graham mj. Nucleic Acids Res. 2014 Jul;42(13):8796-807. doi: 10.1093/nar/gku531. Epub 2014 Jul 3. Nucleic Acids Res. 2014. PMID: 24992960 Free PMC article.

2

Tritium labeling of antisense oligonucleotides by exchange with tritiated water.

Graham MJ, Freier SM, Crooke RM, Ecker DJ, Maslova RN, Lesnik EA. Graham MJ, et al. Nucleic Acids Res. 1993 Aug 11;21(16):3737-43. doi: 10.1093/nar/21.16.3737. Nucleic Acids Res. 1993. PMID: 8367289 Free PMC article.

3

Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications.

McKay RA, Cummins LL, Graham MJ, Lesnik EA, Owens SR, Winniman M, Dean NM. McKay RA, et al. Among authors: graham mj. Nucleic Acids Res. 1996 Feb 1;24(3):411-7. doi: 10.1093/nar/24.3.411. Nucleic Acids Res. 1996. PMID: 8602351 Free PMC article.

4

Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice.

Butler M, Crooke RM, Graham MJ, Lemonidis KM, Lougheed M, Murray SF, Witchell D, Steinbrecher U, Bennett CF. Butler M, et al. Among authors: graham mj. J Pharmacol Exp Ther. 2000 Feb;292(2):489-96. J Pharmacol Exp Ther. 2000. PMID: 10640284

5

Variations in mRNA content have no effect on the potency of antisense oligonucleotides.

Miraglia L, Watt AT, Graham MJ, Crooke ST. Miraglia L, et al. Among authors: graham mj. Antisense Nucleic Acid Drug Dev. 2000 Dec;10(6):453-61. doi: 10.1089/oli.1.2000.10.453. Antisense Nucleic Acid Drug Dev. 2000. PMID: 11198929

6

Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration.

Graham MJ, Crooke ST, Lemonidis KM, Gaus HJ, Templin MV, Crooke RM. Graham MJ, et al. Biochem Pharmacol. 2001 Aug 1;62(3):297-306. doi: 10.1016/s0006-2952(01)00669-4. Biochem Pharmacol. 2001. PMID: 11434902

7

Antisense properties of 2'-O-dimethylaminooxyethyl (2'-O-DMAOE) oligonucleotides.

Prakash TP, Kawasaki AM, Johnston JF, Graham MJ, Condon TP, Manoharan M. Prakash TP, et al. Among authors: graham mj. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):829-32. doi: 10.1081/NCN-100002439. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11563125

8

2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo.

Prakash TP, Johnston JF, Graham MJ, Condon TP, Manoharan M. Prakash TP, et al. Among authors: graham mj. Nucleic Acids Res. 2004 Feb 3;32(2):828-33. doi: 10.1093/nar/gkh220. Print 2004. Nucleic Acids Res. 2004. PMID: 14762210 Free PMC article.

9

An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis.

Crooke RM, Graham MJ, Lemonidis KM, Whipple CP, Koo S, Perera RJ. Crooke RM, et al. Among authors: graham mj. J Lipid Res. 2005 May;46(5):872-84. doi: 10.1194/jlr.M400492-JLR200. Epub 2005 Feb 16. J Lipid Res. 2005. PMID: 15716585 Free article.

10

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.

Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M, Watts L, Booten SL, Graham M, McKay R, Subramaniam A, Propp S, Lollo BA, Freier S, Bennett CF, Bhanot S, Monia BP. Esau C, et al. Cell Metab. 2006 Feb;3(2):87-98. doi: 10.1016/j.cmet.2006.01.005. Cell Metab. 2006. PMID: 16459310 Free article.

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