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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B. Hillig RC, et al. Among authors: graham k. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25. Proc Natl Acad Sci U S A. 2019. PMID: 30683722 Free PMC article.
Preclinical evaluation of BAY 1075553, a novel (18)F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer.
Lesche R, Kettschau G, Gromov AV, Böhnke N, Borkowski S, Mönning U, Hegele-Hartung C, Döhr O, Dinkelborg LM, Graham K. Lesche R, et al. Among authors: graham k. Eur J Nucl Med Mol Imaging. 2014 Jan;41(1):89-101. doi: 10.1007/s00259-013-2527-3. Epub 2013 Aug 17. Eur J Nucl Med Mol Imaging. 2014. PMID: 23955632
D-18F-fluoromethyl tyrosine imaging of bone metastases in a mouse model.
Zitzmann-Kolbe S, Strube A, Frisk AL, Käkönen SM, Tsukada H, Hauff P, Berndorff D, Graham K. Zitzmann-Kolbe S, et al. Among authors: graham k. J Nucl Med. 2010 Oct;51(10):1632-6. doi: 10.2967/jnumed.110.078899. Epub 2010 Sep 16. J Nucl Med. 2010. PMID: 20847178 Free article.
First clinical results of (D)-18F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in patients with non-small cell lung cancer and head and neck squamous cell carcinoma.
Burger IA, Zitzmann-Kolbe S, Pruim J, Friebe M, Graham K, Stephens A, Dinkelborg L, Kowal K, Schibli R, Luurtsema G, Maas B, Horn-Tutic M, Haerle SK, Wiegers J, Schaefer NG, Hany TF, von Schulthess GK. Burger IA, et al. Among authors: graham k. J Nucl Med. 2014 Nov;55(11):1778-85. doi: 10.2967/jnumed.114.140699. Epub 2014 Sep 25. J Nucl Med. 2014. PMID: 25256060 Free article.
Comparison of [(11)C]Choline ([(11)C]CHO) and [(18)F]Bombesin (BAY 86-4367) as Imaging Probes for Prostate Cancer in a PC-3 Prostate Cancer Xenograft Model.
Schwarzenböck SM, Schmeja P, Kurth J, Souvatzoglou M, Nawroth R, Treiber U, Kundt G, Berndt S, Graham K, Senekowitsch-Schmidtke R, Schwaiger M, Ziegler SI, Dinkelborg L, Wester HJ, Krause BJ. Schwarzenböck SM, et al. Among authors: graham k. Mol Imaging Biol. 2016 Jun;18(3):393-401. doi: 10.1007/s11307-015-0901-1. Mol Imaging Biol. 2016. PMID: 26483088
Dosimetry and first clinical evaluation of the new 18F-radiolabeled bombesin analogue BAY 864367 in patients with prostate cancer.
Sah BR, Burger IA, Schibli R, Friebe M, Dinkelborg L, Graham K, Borkowski S, Bacher-Stier C, Valencia R, Srinivasan A, Hany TF, Mu L, Wild PJ, Schaefer NG. Sah BR, et al. Among authors: graham k. J Nucl Med. 2015 Mar;56(3):372-8. doi: 10.2967/jnumed.114.147116. Epub 2015 Feb 12. J Nucl Med. 2015. PMID: 25678494 Free article.
1,441 results