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Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue.
Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Zhu Y, Liu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA. Song A, et al. Among authors: gradinaru v. J Clin Invest. 2020 Jan 2;130(1):247-257. doi: 10.1172/JCI129167. J Clin Invest. 2020. PMID: 31573981 Free PMC article.
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Chen X, et al. Among authors: gradinaru v. Nat Commun. 2023 Jun 8;14(1):3345. doi: 10.1038/s41467-023-38582-7. Nat Commun. 2023. PMID: 37291094 Free PMC article.
Spatial transcriptomics for profiling the tropism of viral vectors in tissues.
Jang MJ, Coughlin GM, Jackson CR, Chen X, Chuapoco MR, Vendemiatti JL, Wang AZ, Gradinaru V. Jang MJ, et al. Among authors: gradinaru v. Nat Biotechnol. 2023 Sep;41(9):1272-1286. doi: 10.1038/s41587-022-01648-w. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702899 Free PMC article.
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.
Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L. Patriarchi T, et al. Among authors: gradinaru v. Science. 2018 Jun 29;360(6396):eaat4422. doi: 10.1126/science.aat4422. Epub 2018 May 31. Science. 2018. PMID: 29853555 Free PMC article.
Systemic AAV vectors for widespread and targeted gene delivery in rodents.
Challis RC, Ravindra Kumar S, Chan KY, Challis C, Beadle K, Jang MJ, Kim HM, Rajendran PS, Tompkins JD, Shivkumar K, Deverman BE, Gradinaru V. Challis RC, et al. Among authors: gradinaru v. Nat Protoc. 2019 Feb;14(2):379-414. doi: 10.1038/s41596-018-0097-3. Nat Protoc. 2019. PMID: 30626963
168 results