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Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis.
Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A. Elwakeel E, et al. Among authors: gradhand e. Cancer Res. 2022 Apr 1;82(7):1380-1395. doi: 10.1158/0008-5472.CAN-21-2116. Cancer Res. 2022. PMID: 35105690
An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity.
Wynendaele J, Böhnke A, Leucci E, Nielsen SJ, Lambertz I, Hammer S, Sbrzesny N, Kubitza D, Wolf A, Gradhand E, Balschun K, Braicu I, Sehouli J, Darb-Esfahani S, Denkert C, Thomssen C, Hauptmann S, Lund A, Marine JC, Bartel F. Wynendaele J, et al. Among authors: gradhand e. Cancer Res. 2010 Dec 1;70(23):9641-9. doi: 10.1158/0008-5472.CAN-10-0527. Epub 2010 Nov 16. Cancer Res. 2010. PMID: 21084273
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.
Atwal GS, Kirchhoff T, Bond EE, Montagna M, Menin C, Bertorelle R, Scaini MC, Bartel F, Böhnke A, Pempe C, Gradhand E, Hauptmann S, Offit K, Levine AJ, Bond GL. Atwal GS, et al. Among authors: gradhand e. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10236-41. doi: 10.1073/pnas.0901298106. Epub 2009 Jun 4. Proc Natl Acad Sci U S A. 2009. PMID: 19497887 Free PMC article.
Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy.
Särchen V, Shanmugalingam S, Kehr S, Reindl LM, Greze V, Wiedemann S, Boedicker C, Jacob M, Bankov K, Becker N, Wehner S, Theilen TM, Gretser S, Gradhand E, Kummerow C, Ullrich E, Vogler M. Särchen V, et al. Among authors: gradhand e. Cell Death Discov. 2022 Jan 10;8(1):11. doi: 10.1038/s41420-021-00812-6. Cell Death Discov. 2022. PMID: 35013156 Free PMC article.
Mid-Gestation lethality of Atxn2l-Ablated Mice.
Key J, Harter PN, Sen NE, Gradhand E, Auburger G, Gispert S. Key J, et al. Among authors: gradhand e. Int J Mol Sci. 2020 Jul 20;21(14):5124. doi: 10.3390/ijms21145124. Int J Mol Sci. 2020. PMID: 32698485 Free PMC article.
41 results