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ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain.
Stratoulias V, Ruiz R, Kanatani S, Osman AM, Keane L, Armengol JA, Rodríguez-Moreno A, Murgoci AN, García-Domínguez I, Alonso-Bellido I, González Ibáñez F, Picard K, Vázquez-Cabrera G, Posada-Pérez M, Vernoux N, Tejera D, Grabert K, Cheray M, González-Rodríguez P, Pérez-Villegas EM, Martínez-Gallego I, Lastra-Romero A, Brodin D, Avila-Cariño J, Cao Y, Airavaara M, Uhlén P, Heneka MT, Tremblay MÈ, Blomgren K, Venero JL, Joseph B. Stratoulias V, et al. Among authors: grabert k. Nat Neurosci. 2023 Jun;26(6):1008-1020. doi: 10.1038/s41593-023-01326-3. Epub 2023 May 11. Nat Neurosci. 2023. PMID: 37169859 Free PMC article.
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. Rojo R, et al. Among authors: grabert k. Nat Commun. 2019 Jul 19;10(1):3215. doi: 10.1038/s41467-019-11053-8. Nat Commun. 2019. PMID: 31324781 Free PMC article.
A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling.
Stables J, Green EK, Sehgal A, Patkar OL, Keshvari S, Taylor I, Ashcroft ME, Grabert K, Wollscheid-Lengeling E, Szymkowiak S, McColl BW, Adamson A, Humphreys NE, Mueller W, Starobova H, Vetter I, Shabestari SK, Blurton-Jones MM, Summers KM, Irvine KM, Pridans C, Hume DA. Stables J, et al. Among authors: grabert k. Development. 2022 Apr 15;149(8):dev200237. doi: 10.1242/dev.200237. Epub 2022 Mar 25. Development. 2022. PMID: 35333324 Free PMC article.
Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus.
Pridans C, Raper A, Davis GM, Alves J, Sauter KA, Lefevre L, Regan T, Meek S, Sutherland L, Thomson AJ, Clohisey S, Bush SJ, Rojo R, Lisowski ZM, Wallace R, Grabert K, Upton KR, Tsai YT, Brown D, Smith LB, Summers KM, Mabbott NA, Piccardo P, Cheeseman MT, Burdon T, Hume DA. Pridans C, et al. Among authors: grabert k. J Immunol. 2018 Nov 1;201(9):2683-2699. doi: 10.4049/jimmunol.1701783. Epub 2018 Sep 24. J Immunol. 2018. PMID: 30249809 Free PMC article.
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