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Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype.
Zanoni P, Steindl K, Sengupta D, Joset P, Bahr A, Sticht H, Lang-Muritano M, van Ravenswaaij-Arts CMA, Shinawi M, Andrews M, Attie-Bitach T, Maystadt I, Belnap N, Benoit V, Delplancq G, de Vries BBA, Grotto S, Lacombe D, Larson A, Mourmans J, Õunap K, Petrilli G, Pfundt R, Ramsey K, Blok LS, Tsatsaris V, Vitobello A, Faivre L, Wheeler PG, Wevers MR, Wojcik M, Zweier M, Gozani O, Rauch A. Zanoni P, et al. Among authors: gozani o. Genet Med. 2021 Aug;23(8):1474-1483. doi: 10.1038/s41436-021-01158-1. Epub 2021 May 3. Genet Med. 2021. PMID: 33941880 Free PMC article.
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Li W, Tian W, Yuan G, Deng P, Sengupta D, Cheng Z, Cao Y, Ren J, Qin Y, Zhou Y, Jia Y, Gozani O, Patel DJ, Wang Z. Li W, et al. Among authors: gozani o. Nature. 2021 Feb;590(7846):498-503. doi: 10.1038/s41586-020-03069-8. Epub 2020 Dec 23. Nature. 2021. PMID: 33361816 Free PMC article.
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis.
Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Lyu R, Caporicci M, Morales Benitez A, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko Ł, Li W, Mazur PK, Gozani O. Sengupta D, et al. Among authors: gozani o. Mol Cell. 2021 Nov 4;81(21):4481-4492.e9. doi: 10.1016/j.molcel.2021.08.034. Epub 2021 Sep 22. Mol Cell. 2021. PMID: 34555356 Free PMC article.
Modulation of p53 function by SET8-mediated methylation at lysine 382.
Shi X, Kachirskaia I, Yamaguchi H, West LE, Wen H, Wang EW, Dutta S, Appella E, Gozani O. Shi X, et al. Among authors: gozani o. Mol Cell. 2007 Aug 17;27(4):636-46. doi: 10.1016/j.molcel.2007.07.012. Mol Cell. 2007. PMID: 17707234 Free PMC article.
Regulation of p53 function by lysine methylation.
West LE, Gozani O. West LE, et al. Among authors: gozani o. Epigenomics. 2011 Jun;3(3):361-9. doi: 10.2217/EPI.11.21. Epigenomics. 2011. PMID: 21826189 Free PMC article.
Methylation by Set9 modulates FoxO3 stability and transcriptional activity.
Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Calnan DR, et al. Among authors: gozani o. Aging (Albany NY). 2012 Jul;4(7):462-79. doi: 10.18632/aging.100471. Aging (Albany NY). 2012. PMID: 22820736 Free PMC article.
Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.
Carlson SM, Gozani O. Carlson SM, et al. Among authors: gozani o. Cold Spring Harb Perspect Med. 2016 Nov 1;6(11):a026435. doi: 10.1101/cshperspect.a026435. Cold Spring Harb Perspect Med. 2016. PMID: 27580749 Free PMC article. Review.
123 results