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Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree.
Raab M, Christodoulou E, Krishnankutty R, Gradinaru A, Walker AD, Olaizola P, Younger NT, Lyons AM, Jarman EJ, Gournopanos K, von Kriegsheim A, Waddell SH, Boulter L. Raab M, et al. Among authors: gournopanos k. J Hepatol. 2024 Mar 7:S0168-8278(24)00149-1. doi: 10.1016/j.jhep.2024.02.030. Online ahead of print. J Hepatol. 2024. PMID: 38460794 Free article.
A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease.
Waddell SH, Yao Y, Olaizola P, Walker A, Jarman EJ, Gournopanos K, Gradinaru A, Christodoulou E, Gautier P, Boerrigter MM, Cadamuro M, Fabris L, Drenth JP, Kendall TJ, Banales JM, Khamseh A, Mill P, Boulter L. Waddell SH, et al. Among authors: gournopanos k. Sci Transl Med. 2023 Sep 13;15(713):eabq5930. doi: 10.1126/scitranslmed.abq5930. Epub 2023 Sep 13. Sci Transl Med. 2023. PMID: 37703354 Free PMC article.
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01.
Jarman EJ, Horcas-Lopez M, Waddell SH, MacMaster S, Gournopanos K, Soong DYH, Musialik KI, Tsokkou P, Ng ME, Cambridge WA, Wilson DH, Kagey MH, Newman W, Pollard JW, Boulter L. Jarman EJ, et al. Among authors: gournopanos k. Liver Int. 2023 Jan;43(1):208-220. doi: 10.1111/liv.15383. Epub 2022 Sep 15. Liver Int. 2023. PMID: 35924447 Free PMC article.
In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma.
Younger NT, Wilson ML, Martinez Lyons A, Jarman EJ, Meynert AM, Grimes GR, Gournopanos K, Waddell SH, Tennant PA, Wilson DH, Guest RV, Wigmore SJ, Acosta JC, Kendall TJ, Taylor MS, Sproul D, Mill P, Boulter L. Younger NT, et al. Among authors: gournopanos k. Cancer Res. 2022 Apr 15;82(8):1548-1559. doi: 10.1158/0008-5472.CAN-21-2556. Cancer Res. 2022. PMID: 35074757 Free PMC article.