Goulding J - Search Results

1

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.

Koo CZ, Harrison N, Noy PJ, Szyroka J, Matthews AL, Hsia HE, Müller SA, Tüshaus J, Goulding J, Willis K, Apicella C, Cragoe B, Davis E, Keles M, Malinova A, McFarlane TA, Morrison PR, Nguyen HTH, Sykes MC, Ahmed H, Di Maio A, Seipold L, Saftig P, Cull E, Pliotas C, Rubinstein E, Poulter NS, Briddon SJ, Holliday ND, Lichtenthaler SF, Tomlinson MG. Koo CZ, et al. Among authors: goulding j. J Biol Chem. 2020 Sep 4;295(36):12822-12839. doi: 10.1074/jbc.RA120.012601. Epub 2020 Feb 28. J Biol Chem. 2020. PMID: 32111735 Free PMC article.

2

Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles.

Grime RL, Goulding J, Uddin R, Stoddart LA, Hill SJ, Poyner DR, Briddon SJ, Wheatley M. Grime RL, et al. Among authors: goulding j. Nanoscale. 2020 Jun 4;12(21):11518-11525. doi: 10.1039/d0nr01060j. Nanoscale. 2020. PMID: 32428052

3

Detection of genome-edited and endogenously expressed G protein-coupled receptors.

Soave M, Stoddart LA, White CW, Kilpatrick LE, Goulding J, Briddon SJ, Hill SJ. Soave M, et al. Among authors: goulding j. FEBS J. 2021 Apr;288(8):2585-2601. doi: 10.1111/febs.15729. Epub 2021 Feb 9. FEBS J. 2021. PMID: 33506623 Free PMC article. Review.

4

The use of fluorescence correlation spectroscopy to monitor cell surface β2-adrenoceptors at low expression levels in human embryonic stem cell-derived cardiomyocytes and fibroblasts.

Goulding J, Kondrashov A, Mistry SJ, Melarangi T, Vo NTN, Hoang DM, White CW, Denning C, Briddon SJ, Hill SJ. Goulding J, et al. FASEB J. 2021 Apr;35(4):e21398. doi: 10.1096/fj.202002268R. FASEB J. 2021. PMID: 33710675

5

Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2-adrenoceptor in CRISPR/Cas9 genome-edited HEK293T cells at low expression levels.

Goulding J, Mistry SJ, Soave M, Woolard J, Briddon SJ, White CW, Kellam B, Hill SJ. Goulding J, et al. Pharmacol Res Perspect. 2021 May;9(3):e00779. doi: 10.1002/prp2.779. Pharmacol Res Perspect. 2021. PMID: 34003582 Free PMC article.

6

Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET.

Lay CS, Bridges A, Goulding J, Briddon SJ, Soloviev Z, Craggs PD, Hill SJ. Lay CS, et al. Among authors: goulding j. Cell Chem Biol. 2022 Jan 20;29(1):19-29.e6. doi: 10.1016/j.chembiol.2021.05.002. Epub 2021 May 25. Cell Chem Biol. 2022. PMID: 34038748 Free PMC article.

7

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking.

Lucey M, Ashik T, Marzook A, Wang Y, Goulding J, Oishi A, Broichhagen J, Hodson DJ, Minnion J, Elani Y, Jockers R, Briddon SJ, Bloom SR, Tomas A, Jones B. Lucey M, et al. Among authors: goulding j. Mol Pharmacol. 2021 Oct;100(4):319-334. doi: 10.1124/molpharm.121.000270. Epub 2021 Jul 27. Mol Pharmacol. 2021. PMID: 34315812 Free PMC article.

8

Advances in the application of fluorescence correlation spectroscopy to study detergent purified and encapsulated membrane proteins.

Stoddart LA, Goulding J, Briddon SJ. Stoddart LA, et al. Among authors: goulding j. Int J Biochem Cell Biol. 2022 May;146:106210. doi: 10.1016/j.biocel.2022.106210. Epub 2022 Apr 4. Int J Biochem Cell Biol. 2022. PMID: 35390493 Free article. Review.

9

Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor.

Dekkers S, Caspar B, Goulding J, Kindon ND, Kilpatrick LE, Stoddart LA, Briddon SJ, Kellam B, Hill SJ, Stocks MJ. Dekkers S, et al. Among authors: goulding j. J Med Chem. 2023 Apr 13;66(7):5208-5222. doi: 10.1021/acs.jmedchem.3c00151. Epub 2023 Mar 21. J Med Chem. 2023. PMID: 36944083 Free PMC article.

10

Application of BRET to monitor ligand binding to GPCRs.

Stoddart LA, Johnstone EKM, Wheal AJ, Goulding J, Robers MB, Machleidt T, Wood KV, Hill SJ, Pfleger KDG. Stoddart LA, et al. Among authors: goulding j. Nat Methods. 2015 Jul;12(7):661-663. doi: 10.1038/nmeth.3398. Epub 2015 Jun 1. Nat Methods. 2015. PMID: 26030448 Free PMC article.

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