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Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase.
Sakamoto Y, Suzuki Y, Nakamura A, Watanabe Y, Sekiya M, Roppongi S, Kushibiki C, Iizuka I, Tani O, Sakashita H, Inaka K, Tanaka H, Yamada M, Ohta K, Honma N, Shida Y, Ogasawara W, Nakanishi-Matsui M, Nonaka T, Gouda H, Tanaka N. Sakamoto Y, et al. Among authors: gouda h. Sci Rep. 2019 Sep 19;9(1):13587. doi: 10.1038/s41598-019-49984-3. Sci Rep. 2019. PMID: 31537874 Free PMC article.
Crystallization and preliminary X-ray crystallographic studies of dipeptidyl peptidase 11 from Porphyromonas gingivalis.
Sakamoto Y, Suzuki Y, Iizuka I, Tateoka C, Roppongi S, Fujimoto M, Gouda H, Nonaka T, Ogasawara W, Tanaka N. Sakamoto Y, et al. Among authors: gouda h. Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):206-10. doi: 10.1107/S2053230X15000424. Epub 2015 Jan 28. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 25664797 Free PMC article.
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.
Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Yamamoto N, et al. Among authors: gouda h. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4176-4179. doi: 10.1016/j.bmcl.2017.07.011. Epub 2017 Jul 4. Bioorg Med Chem Lett. 2017. PMID: 28739044
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase.
Takahara S, Nakagawa K, Uchiyama T, Yoshida T, Matsumoto K, Kawasumi Y, Mizuguchi M, Obita T, Watanabe Y, Hayakawa D, Gouda H, Mori H, Toyooka N. Takahara S, et al. Among authors: gouda h. Bioorg Med Chem Lett. 2018 Feb 1;28(3):441-445. doi: 10.1016/j.bmcl.2017.12.021. Epub 2017 Dec 13. Bioorg Med Chem Lett. 2018. PMID: 29277459
Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.
Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Ohrui S, et al. Among authors: gouda h. Bioorg Med Chem Lett. 2018 Feb 15;28(4):774-777. doi: 10.1016/j.bmcl.2017.12.069. Epub 2017 Dec 30. Bioorg Med Chem Lett. 2018. PMID: 29338909
In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor.
Takasaki I, Watanabe A, Yokai M, Watanabe Y, Hayakawa D, Nagashima R, Fukuchi M, Okada T, Toyooka N, Miyata A, Gouda H, Kurihara T. Takasaki I, et al. Among authors: gouda h. J Pharmacol Exp Ther. 2018 Apr;365(1):1-8. doi: 10.1124/jpet.117.245415. Epub 2018 Jan 23. J Pharmacol Exp Ther. 2018. PMID: 29363578
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.
Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Yamamoto N, et al. Among authors: gouda h. Bioorg Med Chem. 2019 Apr 15;27(8):1747-1758. doi: 10.1016/j.bmc.2019.03.010. Epub 2019 Mar 5. Bioorg Med Chem. 2019. PMID: 30871861
216 results