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Resting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α.
Pelletier A, Nelius E, Fan Z, Khatchatourova E, Alvarado-Diaz A, He J, Krzywinska E, Sobecki M, Nagarajan S, Kerdiles Y, Fandrey J, Gotthardt D, Sexl V, de Bock K, Stockmann C. Pelletier A, et al. Among authors: gotthardt d. EMBO Rep. 2023 Jun 5;24(6):e56156. doi: 10.15252/embr.202256156. Epub 2023 Mar 29. EMBO Rep. 2023. PMID: 36987917 Free PMC article.
CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance.
Putz EM, Gotthardt D, Hoermann G, Csiszar A, Wirth S, Berger A, Straka E, Rigler D, Wallner B, Jamieson AM, Pickl WF, Zebedin-Brandl EM, Müller M, Decker T, Sexl V. Putz EM, et al. Among authors: gotthardt d. Cell Rep. 2013 Aug 15;4(3):437-44. doi: 10.1016/j.celrep.2013.07.012. Epub 2013 Aug 8. Cell Rep. 2013. PMID: 23933255 Free PMC article.
NK cell development in bone marrow and liver: site matters.
Gotthardt D, Prchal-Murphy M, Seillet C, Glasner A, Mandelboim O, Carotta S, Sexl V, Putz EM. Gotthardt D, et al. Genes Immun. 2014 Dec;15(8):584-7. doi: 10.1038/gene.2014.55. Epub 2014 Oct 16. Genes Immun. 2014. PMID: 25319498
STAT1-S727 - the license to kill.
Putz EM, Gotthardt D, Sexl V. Putz EM, et al. Among authors: gotthardt d. Oncoimmunology. 2014 Dec 13;3(9):e955441. doi: 10.4161/21624011.2014.955441. eCollection 2014 Oct. Oncoimmunology. 2014. PMID: 25941617 Free PMC article.
In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity.
Prchal-Murphy M, Witalisz-Siepracka A, Bednarik KT, Putz EM, Gotthardt D, Meissl K, Sexl V, Müller M, Strobl B. Prchal-Murphy M, et al. Among authors: gotthardt d. Oncoimmunology. 2015 May 26;4(11):e1047579. doi: 10.1080/2162402X.2015.1047579. eCollection 2015 Nov. Oncoimmunology. 2015. PMID: 26451322 Free PMC article.
STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion.
Gotthardt D, Putz EM, Grundschober E, Prchal-Murphy M, Straka E, Kudweis P, Heller G, Bago-Horvath Z, Witalisz-Siepracka A, Cumaraswamy AA, Gunning PT, Strobl B, Müller M, Moriggl R, Stockmann C, Sexl V. Gotthardt D, et al. Cancer Discov. 2016 Apr;6(4):414-29. doi: 10.1158/2159-8290.CD-15-0732. Epub 2016 Feb 12. Cancer Discov. 2016. PMID: 26873347
Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity.
Putz EM, Majoros A, Gotthardt D, Prchal-Murphy M, Zebedin-Brandl EM, Fux DA, Schlattl A, Schreiber RD, Carotta S, Müller M, Gerner C, Decker T, Sexl V. Putz EM, et al. Among authors: gotthardt d. Oncoimmunology. 2016 May 19;5(9):e1186314. doi: 10.1080/2162402X.2016.1186314. eCollection 2016. Oncoimmunology. 2016. PMID: 27757297 Free PMC article.
190 results