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The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.
Kozawa K, Sekai M, Ohba K, Ito S, Sako H, Maruyama T, Kakeno M, Shirai T, Kuromiya K, Kamasaki T, Kohashi K, Tanaka S, Ishikawa S, Sato N, Asano S, Suzuki H, Tanimura N, Mukai Y, Gotoh N, Tanino M, Tanaka S, Natsuga K, Soga T, Nakamura T, Yabuta Y, Saitou M, Ito T, Matsuura K, Tsunoda M, Kikumori T, Iida T, Mizutani Y, Miyai Y, Kaibuchi K, Enomoto A, Fujita Y. Kozawa K, et al. Among authors: gotoh n. Curr Biol. 2021 Jul 26;31(14):3086-3097.e7. doi: 10.1016/j.cub.2021.04.078. Epub 2021 Jun 3. Curr Biol. 2021. PMID: 34087104 Free article.
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike SI, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N. Nishimura T, et al. Among authors: gotoh n. Oncogene. 2019 Apr;38(14):2464-2481. doi: 10.1038/s41388-018-0589-1. Epub 2018 Dec 7. Oncogene. 2019. PMID: 30532069 Free PMC article.
Upregulation of S100A10 in metastasized breast cancer stem cells.
Yanagi H, Watanabe T, Nishimura T, Hayashi T, Kono S, Tsuchida H, Hirata M, Kijima Y, Takao S, Okada S, Suzuki M, Imaizumi K, Kawada K, Minami H, Gotoh N, Shimono Y. Yanagi H, et al. Among authors: gotoh n. Cancer Sci. 2020 Dec;111(12):4359-4370. doi: 10.1111/cas.14659. Epub 2020 Oct 11. Cancer Sci. 2020. PMID: 32976661 Free PMC article.
The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
Takeuchi Y, Kimura N, Murayama T, Machida Y, Iejima D, Nishimura T, Terashima M, Wang Y, Li M, Sakamoto R, Yamamoto M, Itano N, Inoue Y, Ito M, Yoshida N, Inoue JI, Akashi K, Saya H, Fujita K, Kuroda M, Kitabayashi I, Voon D, Suzuki T, Tojo A, Gotoh N. Takeuchi Y, et al. Among authors: gotoh n. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2103658118. doi: 10.1073/pnas.2103658118. Proc Natl Acad Sci U S A. 2021. PMID: 34663724 Free PMC article.
432 results