Gotina L - Search Results

1

Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R.

Ackmann J, Brüge A, Gotina L, Lim S, Jahreis K, Vollbrecht AL, Kim YK, Pae AN, Labus J, Ponimaskin E. Ackmann J, et al. Among authors: gotina l. Cell Commun Signal. 2024 Apr 19;22(1):233. doi: 10.1186/s12964-024-01612-y. Cell Commun Signal. 2024. PMID: 38641599 Free PMC article.

2

NeuM: A Neuron-Selective Probe Incorporates into Live Neuronal Membranes via Enhanced Clathrin-Mediated Endocytosis in Primary Neurons.

Sung Y, Gotina L, Kim KH, Lee JY, Shin S, Aziz H, Kang DM, Liu X, Hong NK, Lee HG, Lee JS, Ku H, Jeong C, Pae AN, Lim S, Chang YT, Kim YK. Sung Y, et al. Among authors: gotina l. Angew Chem Int Ed Engl. 2024 Jan 15;63(3):e202312942. doi: 10.1002/anie.202312942. Epub 2023 Dec 15. Angew Chem Int Ed Engl. 2024. PMID: 38062619

3

Exploration of Tetrahydroisoquinoline- and Benzo[c]azepine-Based Sphingosine 1-Phosphate Receptor 1 Agonists for the Treatment of Multiple Sclerosis.

Cha E, Kim J, Gotina L, Kim J, Kim HJ, Seo SH, Park JE, Joo J, Kang M, Lee J, Hwang H, Kim HJ, Pae AN, Park KD, Park JH, Lim SM. Cha E, et al. Among authors: gotina l. J Med Chem. 2023 Aug 10;66(15):10381-10412. doi: 10.1021/acs.jmedchem.3c00498. Epub 2023 Jul 25. J Med Chem. 2023. PMID: 37489798

4

Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants.

Lee EH, Park JE, Gotina L, Han YE, Viswanath ANI, Yoo S, Moon B, Hwang JY, Park WK, Cho Y, Song C, Min SJ, Hwang EM, Lee H, Pae AN, Roh EJ, Oh SJ. Lee EH, et al. Among authors: gotina l. Biomed Pharmacother. 2023 Sep;165:115139. doi: 10.1016/j.biopha.2023.115139. Epub 2023 Jul 15. Biomed Pharmacother. 2023. PMID: 37454597 Free article.

5

Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches.

Nada H, Lee K, Gotina L, Pae AN, Elkamhawy A. Nada H, et al. Among authors: gotina l. Comput Biol Med. 2022 Mar;142:105217. doi: 10.1016/j.compbiomed.2022.105217. Epub 2022 Jan 6. Comput Biol Med. 2022. PMID: 35032738

6

Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress.

Elsherbeny MH, Kim J, Gouda NA, Gotina L, Cho J, Pae AN, Lee K, Park KD, Elkamhawy A, Roh EJ. Elsherbeny MH, et al. Among authors: gotina l. Antioxidants (Basel). 2021 Oct 19;10(10):1641. doi: 10.3390/antiox10101641. Antioxidants (Basel). 2021. PMID: 34679775 Free PMC article.

7

Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action.

Elkamhawy A, Kim HJ, Elsherbeny MH, Paik S, Park JH, Gotina L, Abdellattif MH, Gouda NA, Cho J, Lee K, Nim Pae A, Park KD, Roh EJ. Elkamhawy A, et al. Among authors: gotina l. Bioorg Chem. 2021 Nov;116:105352. doi: 10.1016/j.bioorg.2021.105352. Epub 2021 Sep 11. Bioorg Chem. 2021. PMID: 34562673

8

Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase.

Gotina L, Seo SH, Kim CW, Lim SM, Pae AN. Gotina L, et al. Molecules. 2021 May 31;26(11):3314. doi: 10.3390/molecules26113314. Molecules. 2021. PMID: 34073016 Free PMC article.

9

Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion.

Kim TY, Jeon S, Jang Y, Gotina L, Won J, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim S, Lee CJ. Kim TY, et al. Among authors: gotina l. Exp Mol Med. 2021 May;53(5):956-972. doi: 10.1038/s12276-021-00624-9. Epub 2021 May 25. Exp Mol Med. 2021. PMID: 34035463 Free PMC article.

10

Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.

Hwang YJ, Hyeon SJ, Kim Y, Lim S, Lee MY, Kim J, Londhe AM, Gotina L, Kim Y, Pae AN, Cho YS, Seong J, Seo H, Kim YK, Choo H, Ryu H, Min SJ. Hwang YJ, et al. Among authors: gotina l. J Enzyme Inhib Med Chem. 2021 Dec;36(1):856-868. doi: 10.1080/14756366.2021.1900160. J Enzyme Inhib Med Chem. 2021. PMID: 33771089 Free PMC article.

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