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De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth.
Gosens R, Baarsma HA, Heijink IH, Oenema TA, Halayko AJ, Meurs H, Schmidt M. Gosens R, et al. FASEB J. 2010 Mar;24(3):757-68. doi: 10.1096/fj.09-136325. Epub 2009 Nov 11. FASEB J. 2010. PMID: 19906679
Collectively, these data indicate that beta-catenin is an important signaling intermediate in airway smooth muscle growth and that its cellular accumulation and nuclear localization require de novo protein synthesis effected, in part, via H-Ras and MEK.-Gosens, R., …
Collectively, these data indicate that beta-catenin is an important signaling intermediate in airway smooth muscle growth and that its cellu …
A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.
Spanjer AI, Menzen MH, Dijkstra AE, van den Berge M, Boezen HM, Nickle DC, Sin DD, Bossé Y, Brandsma CA, Timens W, Postma DS, Meurs H, Heijink IH, Gosens R. Spanjer AI, et al. Among authors: gosens r. Thorax. 2016 Apr;71(4):312-22. doi: 10.1136/thoraxjnl-2015-206958. Epub 2016 Jan 21. Thorax. 2016. PMID: 26797711
TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.
Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M. Spanjer AI, et al. Among authors: gosens r. FASEB J. 2016 May;30(5):1823-35. doi: 10.1096/fj.201500129. Epub 2016 Feb 5. FASEB J. 2016. PMID: 26849959
Collectively, our findings demonstrate a role for FZD8 in TGF-beta-induced profibrotic signaling and imply that WNT-5B may be the ligand for FZD8 in these responses.-Spanjer, A. I. R., Baarsma, H. A., Oostenbrink, L. M., Jansen, S. R., Kuipers, C. C., Lindner, M., P …
Collectively, our findings demonstrate a role for FZD8 in TGF-beta-induced profibrotic signaling and imply that WNT-5B may be the ligand for …
190 results