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T cells with dysfunctional mitochondria induce multimorbidity and premature senescence.
Desdín-Micó G, Soto-Heredero G, Aranda JF, Oller J, Carrasco E, Gabandé-Rodríguez E, Blanco EM, Alfranca A, Cussó L, Desco M, Ibañez B, Gortazar AR, Fernández-Marcos P, Navarro MN, Hernaez B, Alcamí A, Baixauli F, Mittelbrunn M. Desdín-Micó G, et al. Among authors: gortazar ar. Science. 2020 Jun 19;368(6497):1371-1376. doi: 10.1126/science.aax0860. Epub 2020 May 21. Science. 2020. PMID: 32439659
Targeting Macrophages: Friends or Foes in Disease?
Ardura JA, Rackov G, Izquierdo E, Alonso V, Gortazar AR, Escribese MM. Ardura JA, et al. Among authors: gortazar ar. Front Pharmacol. 2019 Oct 23;10:1255. doi: 10.3389/fphar.2019.01255. eCollection 2019. Front Pharmacol. 2019. PMID: 31708781 Free PMC article. Review.
Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading.
Plotkin LI, Gortazar AR, Davis HM, Condon KW, Gabilondo H, Maycas M, Allen MR, Bellido T. Plotkin LI, et al. Among authors: gortazar ar. J Biol Chem. 2015 Jul 31;290(31):18934-42. doi: 10.1074/jbc.M115.642090. Epub 2015 Jun 17. J Biol Chem. 2015. PMID: 26085098 Free PMC article.
High glucose alters the secretome of mechanically stimulated osteocyte-like cells affecting osteoclast precursor recruitment and differentiation.
Maycas M, Portolés MT, Matesanz MC, Buendía I, Linares J, Feito MJ, Arcos D, Vallet-Regí M, Plotkin LI, Esbrit P, Gortázar AR. Maycas M, et al. Among authors: gortazar ar. J Cell Physiol. 2017 Dec;232(12):3611-3621. doi: 10.1002/jcp.25829. Epub 2017 Apr 25. J Cell Physiol. 2017. PMID: 28138960 Free article.
Control of bone mass and remodeling by PTH receptor signaling in osteocytes.
O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. O'Brien CA, et al. Among authors: gortazar ar. PLoS One. 2008 Aug 13;3(8):e2942. doi: 10.1371/journal.pone.0002942. PLoS One. 2008. PMID: 18698360 Free PMC article.
33 results