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Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents.
Randazzo P, Sinisi R, Gornati D, Bertuolo S, Bencheva L, De Matteo M, Nibbio M, Monteagudo E, Turcano L, Bianconi V, Peruzzi G, Summa V, Bresciani A, Mozzetta C, Di Fabio R. Randazzo P, et al. Among authors: gornati d. Bioorg Med Chem Lett. 2022 Sep 15;72:128858. doi: 10.1016/j.bmcl.2022.128858. Epub 2022 Jun 16. Bioorg Med Chem Lett. 2022. PMID: 35718104
Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult.
Gornati D, Ciccone R, Vinciguerra A, Ippati S, Pannaccione A, Petrozziello T, Pizzi E, Hassan A, Colombo E, Barbini S, Milani M, Caccavone C, Randazzo P, Muzio L, Annunziato L, Menegon A, Secondo A, Mastrangelo E, Pignataro G, Seneci P. Gornati D, et al. J Med Chem. 2021 Jun 24;64(12):8333-8353. doi: 10.1021/acs.jmedchem.1c00305. Epub 2021 Jun 7. J Med Chem. 2021. PMID: 34097384
Trehalose-based neuroprotective autophagy inducers.
Assoni G, Frapporti G, Colombo E, Gornati D, Perez-Carrion MD, Polito L, Seneci P, Piccoli G, Arosio D. Assoni G, et al. Among authors: gornati d. Bioorg Med Chem Lett. 2021 May 15;40:127929. doi: 10.1016/j.bmcl.2021.127929. Epub 2021 Mar 9. Bioorg Med Chem Lett. 2021. PMID: 33705903
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.
Muzio L, Sirtori R, Gornati D, Eleuteri S, Fossaghi A, Brancaccio D, Manzoni L, Ottoboni L, Feo L, Quattrini A, Mastrangelo E, Sorrentino L, Scalone E, Comi G, Marinelli L, Riva N, Milani M, Seneci P, Martino G. Muzio L, et al. Among authors: gornati d. Nat Commun. 2020 Jul 31;11(1):3848. doi: 10.1038/s41467-020-17524-7. Nat Commun. 2020. PMID: 32737286 Free PMC article.
17 results